Lower mitochondrial DNA content relates to high-altitude adaptation in Tibetans
文献类型：期刊论文
| 作者 | Li Y1,2,3; Huang W4; Yu Q1,2,3; Cheng YT1,2,3; Kong QP[*]1,2 |
| 刊名 | MITOCHONDRIAL DNA
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:1页码:753-757 |
| 关键词 | Adaptation carbon dioxide combining power copy number high altitude mitochondrial DNA |
| 通讯作者 | kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Mitochondrial DNA (mtDNA) is crucial to mitochondria in energy production and other physiological functions. When lowlanders arrive at high altitude, the mitochondrial content tends to decrease. However, the mtDNA content of native highlanders share the same feature as lowlanders remains unknown. It is also interesting to dissect the other changes in blood plasma that might accompany the change of mtDNA content. To address these issues, we recruited 241 Tibetan subjects in Tibet and 220 Han subjects in Shaanxi province. Relative mtDNA copy number and blood biochemical indexes were measured. Results show that relative mtDNA copy number in Tibetans is significantly lower as compared to Han subjects; sex, age, blood glucose, triglyceride and total cholesterol show no influence on mtDNA content, but carbon dioxide combining power is negatively correlated with mtDNA content. These results indicate that an increase in CO2 combining power along with lower mtDNA content may provide adaptive potential. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by non-profit grants from National Basic Research Program of China (2012CB518205), Yunnan Province (2011FA024), Natural Science Foundation of China (31123005, 31322029), and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9460]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China 4.Department of Geriatrics, the Third People’s Hospital of Yunnan Province, Kunming, China |
| 推荐引用方式 GB/T 7714 | Li Y,Huang W,Yu Q,et al. Lower mitochondrial DNA content relates to high-altitude adaptation in Tibetans[J]. MITOCHONDRIAL DNA,2016,27(1):753-757. |
| APA | Li Y,Huang W,Yu Q,Cheng YT,&Kong QP[*].(2016).Lower mitochondrial DNA content relates to high-altitude adaptation in Tibetans.MITOCHONDRIAL DNA,27(1),753-757. |
| MLA | Li Y,et al."Lower mitochondrial DNA content relates to high-altitude adaptation in Tibetans".MITOCHONDRIAL DNA 27.1(2016):753-757. |
入库方式： OAI收割
来源：昆明动物研究所
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