Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China
文献类型：期刊论文
| 作者 | Yu Q1; Sun HP2; Chen WQ3; Chen XQ1; Xu Y[*]2; He YH[*]1; Kong QP[*]1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e15245 |
| 通讯作者 | xuyong59@sina.com ; heyonghan@mail.kiz.ac.cn ; kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SNPs) in Europeans with hypertension in Chinese. A total of 1766 samples consisting of 880 subjects with hypertension and 886 controls were collected and the SNPs were genotyped using multiple assays based on the SNaPshot mini-sequencing approach. Our results revealed a significant genotypic association of rs4746172 of VCL with hypertension with a lower frequency of minor allele in male subjects (OR = 0.70, 95% CI: 0.54-0.92, p = 0.011) but not in females. To validate the result, we genotyped the SNPs in another Chinese population with 546 individuals, and got a consistent association for the rs4746172 (OR = 0.56, 95% CI: 0.38-0.82, p = 2.4 × 10(-3)) in males. The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese. |
| 资助信息 | The study was supported by grants from National Basic Research Program of China (2013CB530802), Yunnan Province (2013FB069), Natural Science Foundation of China (31322029, 31460290, 81402761), Kunming Institute of Zoology, Chinese Academy of Sciences (GREKF12-11) and the Foundation Research Project of Jiangsu Province (BK20140361). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9465]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. 2.Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou 215123, China 3.Department of Biochemistry, Jinan University, Guangzhou 510632, China |
| 推荐引用方式 GB/T 7714 | Yu Q,Sun HP,Chen WQ,et al. Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China[J]. SCIENTIFIC REPORTS,2015,5(X):e15245. |
| APA | Yu Q.,Sun HP.,Chen WQ.,Chen XQ.,Xu Y[*].,...&Kong QP[*].(2015).Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China.SCIENTIFIC REPORTS,5(X),e15245. |
| MLA | Yu Q,et al."Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China".SCIENTIFIC REPORTS 5.X(2015):e15245. |
入库方式： OAI收割
来源：昆明动物研究所
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