Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families
文献类型：期刊论文
| 作者 | He YH1,3; Pu SY1,3; Xiao FH1,3,6; Chen XQ1,3; Yan DJ2; Liu YW1,3,6; Lin R4; Liao XP5; Yu Q1,2,6; Cai WW[*]2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e21962 |
| 通讯作者 | caiww591020@163.com ; kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Centenarians are a good healthy aging model. Interestingly, centenarians' offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20-80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20-80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure wereimproved in CEN or their offspring, suggesting these factors may play an important role in familial longevity. |
| 收录类别 | SCI |
| 资助信息 | The study was supported by grants from National Basic Research Program of China (2013CB530802), Yunnan Province (2013FB069), Natural Science Foundation of China (31100909, 31460290), and the Department of Science and Technology of Hainan Province (KJHZ2013-16). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9536]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. 2.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou 571199, China 3.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China 4.Department of Biology, Hainan Medical College, Haikou 571199, China 5.Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou 571199, China 6.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China 7.Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China |
| 推荐引用方式 GB/T 7714 | He YH,Pu SY,Xiao FH,et al. Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families[J]. SCIENTIFIC REPORTS,2016,6(X):e21962. |
| APA | He YH.,Pu SY.,Xiao FH.,Chen XQ.,Yan DJ.,...&Kong QP[*].(2016).Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.SCIENTIFIC REPORTS,6(X),e21962. |
| MLA | He YH,et al."Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families".SCIENTIFIC REPORTS 6.X(2016):e21962. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。