Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations
文献类型：期刊论文
| 作者 | Tanisawa K1,2,3; Arai Y4; Hirose N4; Shimokata H5,6; Yamada Y7; Kawai H8; Kojima M8; Obuchi S8; Hirano H9; Yoshida H9 |
| 刊名 | Journals of Gerontology: Biological Sciences
 |
| 出版日期 | 2017 |
| 卷号 | 72期号:3页码:309–318 |
| 关键词 | Centenarian Human aging Human genetics Longevity |
| 通讯作者 | mtanaka@tmig.or.jp |
| 英文摘要 | Life span is a complex trait regulated by multiple genetic and environmental factors; however, the genetic determinants of extreme longevity have been largely unknown. To identify the functional coding variants associated with extreme longevity, we performed an exome-wide association study (EWAS) on a Japanese population by using an Illumina HumanExome Beadchip and a focused replication study on a Chinese population. The EWAS on two independent Japanese cohorts consisting of 530 nonagenarians/centenarians demonstrated that the G allele of CLEC3B missense variant p.S106G was associated with extreme longevity at the exome-wide level of significance (p = 2.33×10-7, odds ratio [OR] = 1.50). The CLEC3B gene encodes tetranectin, a protein implicated in the mineralization process in osteogenesis as well as in the prognosis and metastasis of cancer. The replication study consisting of 448 Chinese nonagenarians/centenarians showed that the G allele of CLEC3B p.S106G was also associated with extreme longevity (p = .027, OR = 1.51), and the p value of this variant reached 1.87×10-8 in the meta-analysis of Japanese and Chinese populations. In conclusion, the present study identified the CLEC3B p.S106G as a novel longevity-associated variant, raising the novel hypothesis that tetranectin, encoded by CLEC3B, plays a role in human longevity and aging. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; by GMEXT/JSPS KAKENHI Grants (A-25242062, A-22240072, B-21390459, C-26670481, C-21590411, and CER-24650414 to M.T.); by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2015–2019 from the Ministry of Education, Culture, Sports, Science and Technology (S1511017 to M.H.); by Grants-in-Aid for Research on Intractable Diseases (Mitochondrial Disorders; 23-016, 23-116, and 24-005 to M.T.) from the Ministry of Health, Labor, and Welfare of Japan; by the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development, AMED (15ek0109088h0001 and 15ek0109088s0401 to M.T.); by the Takeda Science Foundation (to M.T.); by the Smoking Research Foundation (to T.A. and M.S.); and by the Joint Usage/Research Program of the Medical Research Institute, Tokyo Medical and Dental University (to M.M.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9826]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Japan. Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan. Japan Society for the Promotion of Science, Tokyo, Japan. 2.Center for Supercentenarian Research, Keio University School of Medicine, Tokyo, Japan. 3.Section of Longitudinal Study of Aging, National Institute for Longevity Sciences (NILS-LSA), National Center for Geriatrics and Gerontology, Obu, Japan. Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan. 4.Section of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Japan 5.Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Japan 6.Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan. Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, Japan. 7.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, China. 8.Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Japan 9.Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan. 10.Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Japan. |
| 推荐引用方式 GB/T 7714 | Tanisawa K,Arai Y,Hirose N,et al. Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations[J]. Journals of Gerontology: Biological Sciences,2017,72(3):309–318. |
| APA | Tanisawa K.,Arai Y.,Hirose N.,Shimokata H.,Yamada Y.,...&Tanaka M[*].(2017).Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.Journals of Gerontology: Biological Sciences,72(3),309–318. |
| MLA | Tanisawa K,et al."Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations".Journals of Gerontology: Biological Sciences 72.3(2017):309–318. |
入库方式： OAI收割
来源：昆明动物研究所
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