Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians
文献类型：期刊论文
| 作者 | He YH1,3; Lu X1,3; Lin R5; Perry B6; Chen XQ1,3; Yu Q1,3,4; Cai WW[*]2; Kong QP[*]1,3; Tian JY1,3,4; Yan DJ2 |
| 刊名 | EXPERIMENTAL GERONTOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 83期号:X页码:94–96 |
| 关键词 | Longevity Mitochondrial DNA Evolutionary selection Gender dimorphism |
| 通讯作者 | caiww591020@163.com |
| 合作状况 | 其它 |
| 英文摘要 | The mitochondrion is a double membrane-bound organelle which plays important functional roles in aging and many other complex phenotypes. Transmission of the mitochondrial genome in the matrilineal line causes the evolutionary selection sieve only in females. Theoretically, beneficial or neutral variations are more likely to accumulate and be retained in the female mitochondrial genome during evolution, which may be an initial trigger of gender dimorphism in aging. The asymmetry of evolutionary processes between gender could lead to males and females aging in different ways. If so, gender specific variation loads could be an evolutionary result of maternal heritage of mitochondrial genomes, especially in centenarians who live to an extreme age and are considered as good models for healthy aging. Here, we tested whether the mitochondrial variation loads were associated with altered aging patterns by investigating the mtDNA haplogroup distribution and genetic diversity between female and male centenarians. We found no evidence of differences in aging patterns between genders in centenarians. Our results indicate that the evolutionary consequence of gender dimorphism in mitochondrial genomes is not a factor in the altered aging patterns in human, and that mitochondrial DNA contributes equally to longevity in males and females. (C) 2016 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | Thisworkwassupportedbygrants from theNationalBasic Research Program of China (2013CB530802), the Chinese Academy of Sciences, Yunnan Province (2013FB069), the National Natural Science Founda- tion of China (81500670, 31460290), the open project from State Key Laboratory of Genetic Resources and Evolution (GREKF16-10), and the Hainan Provincial Department of Science and Technology (KJHZ2013-16). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10358]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 2.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou 571199, China 3.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, Chin 4.University of the Chinese Academy of Sciences, Beijing 100049, China 5.Department of Biology, Hainan Medical College, Haikou 571199, China 6.Defence Research Development Canada, Toronto, Ontario M3K 2C9, Canad |
| 推荐引用方式 GB/T 7714 | He YH,Lu X,Lin R,et al. Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians[J]. EXPERIMENTAL GERONTOLOGY,2016,83(X):94–96. |
| APA | He YH.,Lu X.,Lin R.,Perry B.,Chen XQ.,...&Li YC.(2016).Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians.EXPERIMENTAL GERONTOLOGY,83(X),94–96. |
| MLA | He YH,et al."Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians".EXPERIMENTAL GERONTOLOGY 83.X(2016):94–96. |
入库方式： OAI收割
来源：昆明动物研究所
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