DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY
文献类型：期刊论文
| 作者 | He HY1; Pu SY1; Yan DJ3; Liu YW1; Lin R4; Liao XP5; Yang XL1; Ge MX1; Li W2; Cai WW[*]3 |
| 刊名 | ARCHIVES OF BIOLOGICAL SCIENCES
 |
| 出版日期 | 2016 |
| 卷号 | 68期号:3页码:533-540 |
| 关键词 | aging longevity hemoglobin centenarian energy metabolism |
| 通讯作者 | caiww591020@163.com ; kongqp@mail.kiz.ac.cn |
| 英文摘要 | Hemoglobin (HGB) in the blood carries oxygen from the lungs to other organs to produce energy. Calorie restriction has been shown to slow aging and extend lifespan. Thus, we hypothesized that HGB may be associated with human longevity as a link to energy metabolism. To test this hypothesis, HGB levels in the blood of 60 centenarian (CEN) families were measured and its association with age (20-80 and 20-100 years) was studied, as well as the associations of CEN HGB with levels in first generation offspring (F1) and their spouses (F1SP). The results showed no association of HGB with age between 20 and 80 years (r=-0.097, p=0.160); however a strikingly inverse relationship with age between 20 and 100 years (r=-0.526, p<0.001) was revealed. After dividing the samples into four age groups (20-39, 40-59, 60-80 and =100 years), the HGB in CEN were significantly lower than that of F1SP (p<0.001). Interestingly, the HGB levels of CEN were significantly associated with that of F1 (r=0.379, p=0.015) but not with F1SP (r=0.022, p=0.451), suggesting that HGB could be a heritable phenotype. Furthermore, the genes methylenetetrahydrofolate reductase (MTHFR), nuclear receptor subfamily 2, group C, member 1 (NR2C1) and NR2C2 were differentially expressed in CEN when compared to F1SP, which may likely be responsible for the changes in HGB levels. In conclusion, our results suggest that HGB is a heritable phenotype which associates with familial longevity. |
| 收录类别 | SCI |
| 资助信息 | The study was supported by grants from Na- tional Basic Research Program of China (2013CB530802), Yun- nan Province (2013FB069), the Chinese Academy of Sciences, Natural Science Foundation of China (31322029, 31460290), and the Department of Science and Technology of Hainan Province (KJHZ2013-16). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10782]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, Chin 2.Department of Endocrinology, Third People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China 3.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou 571199, China 4.Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou 571199, China 5.Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou 571199, China. |
| 推荐引用方式 GB/T 7714 | He HY,Pu SY,Yan DJ,et al. DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY[J]. ARCHIVES OF BIOLOGICAL SCIENCES,2016,68(3):533-540. |
| APA | He HY.,Pu SY.,Yan DJ.,Liu YW.,Lin R.,...&Xiao FH.(2016).DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY.ARCHIVES OF BIOLOGICAL SCIENCES,68(3),533-540. |
| MLA | He HY,et al."DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY".ARCHIVES OF BIOLOGICAL SCIENCES 68.3(2016):533-540. |
入库方式： OAI收割
来源：昆明动物研究所
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