中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway

文献类型:期刊论文

作者Wang XX1,2; Xiao FH1,2; Kong QP[*]1; Li QG1; Liu JW[1,2]1; He YH1
刊名Oncotarget
出版日期2017
卷号**期号:**页码:published online
关键词DNA methylation calcium-signaling pathway gene expression pan-cancer
通讯作者kongqp@mail.kiz.ac.cn
英文摘要Tumorigenesis is linked to the role of DNA methylation in gene expression regulation. Yet, cancer is a highly heterogeneous disease in which the global pattern of DNA methylation and gene expression, especially across diverse cancers, is not well understood. We investigated DNA methylation status and its association with gene expressions across 12 solid cancer types obtained from The Cancer Genome Atlas. Results showed that global hypermethylation was an important characteristic across all 12 cancer types. Moreover, there were more epigenetically silenced than epigenetically activated genes across the cancers. Further analysis identified epigenetically silenced genes shared in the calcium-signaling pathway across the different cancer types. Reversing the aberrant DNA methylation of genes involved in the calcium-signaling pathway could be an effective strategy for suppressing cancers and developing anti-cancer drugs.
收录类别SCI
资助信息This work was supported by grants from the Chinese Academy of Sciences (KJZD-EW-L14 and QYZDB-SSW- SMC020), National Basic Research Program of China (2012CB518205), National Natural Science Foundation of China (81272309, 31322029, 81602346), and Youth Innovation Promotion Association of the Chinese Academy of Sciences.
语种英语
源URL[http://159.226.149.26:8080/handle/152453/10789]  
专题昆明动物研究所_分子人类学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China
推荐引用方式
GB/T 7714
Wang XX,Xiao FH,Kong QP[*],et al. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway[J]. Oncotarget,2017,**(**):published online.
APA Wang XX,Xiao FH,Kong QP[*],Li QG,Liu JW[1,2],&He YH.(2017).Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.Oncotarget,**(**),published online.
MLA Wang XX,et al."Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway".Oncotarget **.**(2017):published online.

入库方式: OAI收割

来源:昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。