Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway
文献类型：期刊论文
| 作者 | Wang XX1,2; Xiao FH1,2; Kong QP[*]1; Li QG1; Liu JW[1,2]1; He YH1 |
| 刊名 | Oncotarget
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 关键词 | DNA methylation calcium-signaling pathway gene expression pan-cancer |
| 通讯作者 | kongqp@mail.kiz.ac.cn |
| 英文摘要 | Tumorigenesis is linked to the role of DNA methylation in gene expression regulation. Yet, cancer is a highly heterogeneous disease in which the global pattern of DNA methylation and gene expression, especially across diverse cancers, is not well understood. We investigated DNA methylation status and its association with gene expressions across 12 solid cancer types obtained from The Cancer Genome Atlas. Results showed that global hypermethylation was an important characteristic across all 12 cancer types. Moreover, there were more epigenetically silenced than epigenetically activated genes across the cancers. Further analysis identified epigenetically silenced genes shared in the calcium-signaling pathway across the different cancer types. Reversing the aberrant DNA methylation of genes involved in the calcium-signaling pathway could be an effective strategy for suppressing cancers and developing anti-cancer drugs. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Chinese Academy of Sciences (KJZD-EW-L14 and QYZDB-SSW- SMC020), National Basic Research Program of China (2012CB518205), National Natural Science Foundation of China (81272309, 31322029, 81602346), and Youth Innovation Promotion Association of the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10789]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China |
| 推荐引用方式 GB/T 7714 | Wang XX,Xiao FH,Kong QP[*],et al. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway[J]. Oncotarget,2017,**(**):published online. |
| APA | Wang XX,Xiao FH,Kong QP[*],Li QG,Liu JW[1,2],&He YH.(2017).Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.Oncotarget,**(**),published online. |
| MLA | Wang XX,et al."Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway".Oncotarget **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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