Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
文献类型：期刊论文
| 作者 | Wu C1,2; Wang ZM3,4; He J8,9; Kong QP10; Song X5,6; Feng XS7; Abnet CC3 |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2014 |
| 卷号 | 46期号:9页码:1001-+ |
| 通讯作者 | ldwang@zzu.edu.cn ; ptaylor@mail.nih.gov ; lindx72@cicams.ac.cn |
| 英文摘要 | We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS)(1-3) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 x 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 x 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 x 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10798]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100021, Peoples R China 3.NCI, Div Canc Epidemiol & Genet, US Natl Inst Hlth, Bethesda, MD 20892 USA 4.SAIC Frederick Inc, NCI Frederick, Adv Technol Program, Div Canc Epidemiol & Genet,Canc Genome Res Lab, Frederick, MD USA 5.Xinxiang Med Univ, Basic Med Coll, Canc Res Ctr, Dept Pathol, Xinxiang, Peoples R China 6.Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou, Peoples R China 7.Henan Univ Sci & Technol, Affiliated Hosp 1, Clin Lab & Resp Med, Dept Oncol, Luoyang, Peoples R China 8.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100730, Peoples R China 9.Peking Union Med Coll, Beijing 100021, Peoples R China 10.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resource & Evolut, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu C,Wang ZM,He J,et al. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations[J]. NATURE GENETICS,2014,46(9):1001-+. |
| APA | Wu C.,Wang ZM.,He J.,Kong QP.,Song X.,...&Abnet CC.(2014).Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.NATURE GENETICS,46(9),1001-+. |
| MLA | Wu C,et al."Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations".NATURE GENETICS 46.9(2014):1001-+. |
入库方式： OAI收割
来源：昆明动物研究所
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