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Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
文献类型：期刊论文
| 作者 | Wan QL1,2; Zheng SQ1,2; Wu GS3; Luo HR[*]1 |
| 刊名 | EXPERIMENTAL GERONTOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:5页码:499–506 |
| 关键词 | Caenorhabditis elegans Aspirin Lifespan AMPK DAF-16/FOXO Dietary restriction |
| 通讯作者 | luohuairong@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. |
| 收录类别 | SCI |
| 资助信息 | This work was partially supported by the Yunnan provincial government (20080A007), the 100 Talents Program of the Chinese Academy of Sciences, and the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany (P2008-ZZ21 and T2009-KF05). |
| 语种 | 英语 |
| WOS记录号 | WOS:000317182600007 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7614]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Wan QL,Zheng SQ,Wu GS,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499–506. |
| APA | Wan QL,Zheng SQ,Wu GS,&Luo HR[*].(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499–506. |
| MLA | Wan QL,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499–506. |
入库方式： OAI收割
来源：昆明动物研究所
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