Selective recruitment of host factors by HSV-1 replication centers
文献类型：期刊论文
| 作者 | Lang FC1,2; Li X1,2; Vladmirova O3; Li ZR1,2; Chen GJ1; Xiao Y1; Li LH1; Lu DF1,2; Han HB4; Zhou JM[*]1 |
| 刊名 | Zoological research
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:3页码:142-151 |
| 关键词 | CTCF HSV-1 RNA Pol II Viral replication cente gammaH2AX |
| 通讯作者 | zhoujm@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Herpes simplex virus type 1 (HSV-1) enters productive infection after infecting epithelial cells, where it controls the host nucleus to make viral proteins, starts viral DNA synthesis and assembles infectious virions. In this process, replicating viral genomes are organized into replication centers to facilitate viral growth. HSV-1 is known to use host factors, including host chromatin and host transcription regulators, to transcribe its genes; however, the invading virus also encounters host defense and stress responses to inhibit viral growth. Recently, we found that HSV-1 replication centers recruit host factor CTCF but exclude γH2A.X. Thus, HSV-1 replication centers may selectively recruit cellular factors needed for viral growth, while excluding host factors that are deleterious for viral transcription or replication. Here we report that the viral replication centers selectively excluded modified histone H3, including heterochromatin mark H3K9me3, H3S10P and active chromatin mark H3K4me3, but not unmodified H3. We found a dynamic association between the viral replication centers and host RNA polymerase II. The centers also recruited components of the DNA damage response pathway, including 53BP1, BRCA1 and host antiviral protein SP100. Importantly, we found that ATM kinase was needed for the recruitment of CTCF to the viral centers. These results suggest that the HSV-1 replication centers took advantage of host signaling pathways to actively recruit or exclude host factors to benefit viral growth. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by grants from the Yunnan Provincial Government (2013FA051; 2011HA005), the National Science Foundation of China (NSFC 81471966 to JZ and NSFC 31200964 to YX), and the common project of the Panzhihua Science and Technology Bureau from China (2012CY-S-22(9) to HH) |
| 语种 | 英语 |
| 公开日期 | 2015-06-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8335]  |
| 专题 | 昆明动物研究所_基因调控与表达遗传 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.The Wistar Institute, Gene Expression and Regulation Program, Philadelphia PA 19104, USA 4.Biology & Chemistry Engineering College, Panzhihua University, Panzhihua Sichuan 617000, China |
| 推荐引用方式 GB/T 7714 | Lang FC,Li X,Vladmirova O,et al. Selective recruitment of host factors by HSV-1 replication centers[J]. Zoological research,2015,36(3):142-151. |
| APA | Lang FC.,Li X.,Vladmirova O.,Li ZR.,Chen GJ.,...&Zhou JM[*].(2015).Selective recruitment of host factors by HSV-1 replication centers.Zoological research,36(3),142-151. |
| MLA | Lang FC,et al."Selective recruitment of host factors by HSV-1 replication centers".Zoological research 36.3(2015):142-151. |
入库方式： OAI收割
来源：昆明动物研究所
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