The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features
文献类型：期刊论文
| 作者 | Fan ST1; Cai HZ1; Liao Y1; Zhang Y1; HeZL2; YangFM2; Yu WH2; Wang JJ1; XuXL1; Zhou JM3 |
| 刊名 | Viruses
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:X页码:e26 |
| 关键词 | herpes simplex virus type 1 pathology rhesus macaques |
| 通讯作者 | liqihan@imbcams.com.cn |
| 英文摘要 | As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1 in rhesus macaques and the pathological features induced during this infection. Clinical symptoms that manifested in the rhesus macaque during HSV1 infection included vesicular lesions and their pathological features. Viral distribution in the nervous tissues and associated pathologic changes indicated the typical systematic pathological processes associated with viral distribution of HSV1.Interestingly, vesicular lesions recurred in oral skin or in mucosa associated with virus shedding in macaques within four to five months post-infection,and viral latency-associated transcript (LAT) mRNA was found in the trigeminal ganglia (TG)on day 365 post-infection. Neutralization testing and enzyme-linked immunospot (ELISpot) detection of specific T cell responses confirmed the specific immunity induced by HSV1 infection. Thus, rhesus macaques could serve as an infectious model for HSV1 due to their typical clinical symptoms and the pathological recurrence associated with viral latency in nervous tissues. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Peking Union Medical College (PUMC) Youth Fund, the Fundamental Research Funds for the Central Universities (3332016115, 33320140084), the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (2016‐I2M‐1‐019), the National Natural Science Foundation of China (31100127, 31300143) and Yunnan Applied Basic Research Projects (2013FZ128). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10829]  |
| 专题 | 昆明动物研究所_基因调控与表达遗传 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China 2.Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China; 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Fan ST,Cai HZ,Liao Y,et al. The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features[J]. Viruses,2017,9(X):e26. |
| APA | Fan ST.,Cai HZ.,Liao Y.,Zhang Y.,HeZL.,...&Wang LC.(2017).The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features.Viruses,9(X),e26. |
| MLA | Fan ST,et al."The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features".Viruses 9.X(2017):e26. |
入库方式： OAI收割
来源：昆明动物研究所
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