Origin and evolution of new exons in the rodent zinc finger protein 39 gene
文献类型：期刊论文
| 作者 | Peng LX1,2; Zheng HK3; Li X1,2; Yang S2,4; Chen H1,5; Wang W[*]2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2005 |
| 卷号 | 50期号:11页码:1126-1130 |
| 关键词 | new exons origin and evolution zinc finger protein nuclear localization signal peptide |
| ISSN号 | 1001-6538 |
| 通讯作者 | wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The origin of new structures and functions is an important process in evolution. In the past decades, we have obtained some preliminary knowledge of the origin and evolution of new genes. However, as the basic unit of genes, the origin and evolution of exons remain unclear. Because young exons retain the footprints of origination, they can be good materials for studying origin and evolution of new exons. In this paper, we report two young exons in a zinc finger protein gene of rodents. Since they are unique sequences in mouse and rat genome and no homologous sequences were found in the orthologous genes of human and pig, the young exons might originate after the divergence of primates and rodents through exonization of intronic sequences. Strong positive selection was detected in the new exons between mouse and rat, suggesting that these exons have undergone significant functional divergence after the separation of the two species. On the other hand, population genetics data of mouse demonstrate that the new exons have been subject to functional constraint, indicating an important function of the new exons in mouse. Functional analyses suggest that these new exons encode a nuclear localization signal peptide, which may mediate new ways of nuclear protein transport. To our knowledge, this is the first example of the origin and evolution of young exons. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the program of the CAS-Max Planck Junior Scientist Group, the key project of the CAS (Grant No. KSCX2-SW-121) and the National Natu- ral Science Foundation of China (Grant Nos. 30325016 & 30430400). |
| 原文出处 | 2005501126.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4805]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.College of Animal Science and Technology, Northwest Sci-Tech Uni- versity of Agriculture and Forestry, Yangling 712100, Chin 2.CAS-Max Planck Junior Scientist Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 5.Institute of Cellular and Molecular Biology, Xuzhou Normal Univer- sity, Xuzhou 221116, China |
| 推荐引用方式 GB/T 7714 | Peng LX,Zheng HK,Li X,et al. Origin and evolution of new exons in the rodent zinc finger protein 39 gene[J]. CHINESE SCIENCE BULLETIN,2005,50(11):1126-1130. |
| APA | Peng LX,Zheng HK,Li X,Yang S,Chen H,&Wang W[*].(2005).Origin and evolution of new exons in the rodent zinc finger protein 39 gene.CHINESE SCIENCE BULLETIN,50(11),1126-1130. |
| MLA | Peng LX,et al."Origin and evolution of new exons in the rodent zinc finger protein 39 gene".CHINESE SCIENCE BULLETIN 50.11(2005):1126-1130. |
入库方式： OAI收割
来源：昆明动物研究所
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