Origin and evolution of new exons in rodents
文献类型：期刊论文
| 作者 | Wang W[*]1; Zheng HK2; Yang S1,3; Yu HJ4; Li J2; Jiang HF1,3; Su JN[2]2; Yang L2; Zhang JG2; McDermott J5 |
| 刊名 | GENOME RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 15期号:9页码:1258-1264 |
| ISSN号 | 1088-9051 |
| 通讯作者 | wwang@mail.kiz.ac.cn ; gksw@genomics.org.cn ; wangj@genomics.org.cn |
| 英文摘要 | Gene number difference among organisms demonstrates that new gene origination is a fundamental biological process in evolution. Exon shuffling has been universally observed in the formation of new genes. Yet to be learned are the ways new exons originate and evolve, and how often new exons appear. To address these questions, we identified 2695 newly evolved exons in the mouse and rat by comparing the expressed sequences of 12,419 orthologous genes between human and mouse, using 743,856 pig ESTs as the outgroup. The new exon origination rate is about 2.71 x 10(-3) per gene per million years. These new exons have markedly accelerated rates both of nonsynonymous substitutions and of insertions/ deletions (indels). A much higher proportion of new exons have Kappa(a)/Kappa(s) ratios > 1 (where K-a is the nonsynonymous substitution rate and K-s is the synonymous substitution rate) than K do the old exons shared by human and mouse, implying a role of positive selection in the rapid evolution. The majority of these new exons have sequences unique in the genome, suggesting that most new exons might originate through "exonization" of intronic sequences. Most of the new exons appear to be alternative exons that are expressed at low levels. |
| 收录类别 | SCI |
| 资助信息 | W.W. was supported by a CAS-Max Planck Society Fellowship, a CAS key project grant (No. KSCX2- SW-121), a NSFC award (No. 30325016) to distinguished young scientists, and a NSFC key grant (No. 30430400). J.W. and G.K.S.W. were sponsored by the Chinese Academy of Sciences, Commission for Economy Planning, Ministry of Science and Technology (2002AA104250; 2001AA231061; 2004AA231050) and National Natural Science Foundation of China. J.W. was also supported by the Danish National Research Foundation (Danish Platform for Integrative Biology). |
| 原文出处 | 2005151258.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4809]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Cellular & Mol Evolut, Max Planck Jr Res Grp, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Yunnan Univ, Key Lab Biodivers Conservat & Utilizat, Kunming 650091, Yunnan, Peoples R China 5.Yunnan Univ, Ctr Human Genet, Kunming 650091, Yunnan, Peoples R China 6.Univ Washington, Dept Microbiol, Computat Genom Grp, Seattle, WA 98195 USA 7.Univ Washington, Dept Med, Genome Ctr, Seattle, WA 98195 USA 8.Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark |
| 推荐引用方式 GB/T 7714 | Wang W[*],Zheng HK,Yang S,et al. Origin and evolution of new exons in rodents[J]. GENOME RESEARCH,2005,15(9):1258-1264. |
| APA | Wang W[*].,Zheng HK.,Yang S.,Yu HJ.,Li J.,...&Wang J[*].(2005).Origin and evolution of new exons in rodents.GENOME RESEARCH,15(9),1258-1264. |
| MLA | Wang W[*],et al."Origin and evolution of new exons in rodents".GENOME RESEARCH 15.9(2005):1258-1264. |
入库方式： OAI收割
来源：昆明动物研究所
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