Origination of an X-linked testes chimeric gene by illegitimate recombination in Drosophila
文献类型：期刊论文
| 作者 | Arguello JR1; Chen Y2; Yang S3; Wang W[*]3; Long M[*]1,2 |
| 刊名 | PLOS GENETICS
 |
| 出版日期 | 2006 |
| 卷号 | 2期号:5页码:745-754 |
| ISSN号 | 1553-7390 |
| 通讯作者 | wwang@mail.kiz.ac.cn ; mlong@midway.uchicago.edu |
| 合作状况 | 其它 |
| 英文摘要 | The formation of chimeric gene structures provides important routes by which novel proteins and functions are introduced into genomes. Signatures of these events have been identified in organisms from wide phylogenic distributions. However, the ability to characterize the early phases of these evolutionary processes has been difficult due to the ancient age of the genes or to the limitations of strictly computational approaches. While examples involving retrotransposition exist, our understanding of chimeric genes originating via illegitimate recombination is limited to speculations based on ancient genes or transfection experiments. Here we report a case of a young chimeric gene that has originated by illegitimate recombination in Drosophila. This gene was created within the last 2-3 million years, prior to the speciation of Drosophila simulans, Drosophila sechellia, and Drosophila mauritiana. The duplication, which involved the Ballchen gene on Chromosome 3R, was partial, removing substantial 3' coding sequence. Subsequent to the duplication onto the X chromosome, intergenic sequence was recruited into the protein-coding region creating a chimeric peptide with similar to 33 new amino acid residues. In addition, a novel intron-containing 5' UTR and novel 3' UTR evolved. We further found that this new X-linked gene has evolved testes-specific expression. Following speciation of the D. simulans complex, this novel gene evolved lineage-specifically with evidence for positive selection acting along the D. simulans branch. |
| 收录类别 | SCI |
| 资助信息 | This work was funded by a National Science Foundation Career Grant (023A168) and National Institutes of Health grant (R01GM065429). |
| 原文出处 | 20062745.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4817]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois, United States of America 2.Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America 3.Chinese Academy of Sciences–Max Planck Junior Scientist Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Arguello JR,Chen Y,Yang S,et al. Origination of an X-linked testes chimeric gene by illegitimate recombination in Drosophila[J]. PLOS GENETICS,2006,2(5):745-754. |
| APA | Arguello JR,Chen Y,Yang S,Wang W[*],&Long M[*].(2006).Origination of an X-linked testes chimeric gene by illegitimate recombination in Drosophila.PLOS GENETICS,2(5),745-754. |
| MLA | Arguello JR,et al."Origination of an X-linked testes chimeric gene by illegitimate recombination in Drosophila".PLOS GENETICS 2.5(2006):745-754. |
入库方式： OAI收割
来源：昆明动物研究所
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