On the origin and evolution of new genes-a genomic and experimental perspective
文献类型：期刊论文
| 作者 | Zhou Q; Wang W[*] |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2008 |
| 卷号 | 35期号:11页码:639-648 |
| 关键词 | origin of new genes gene duplication de novo origination chimeric genes |
| ISSN号 | 1673-8527 |
| 通讯作者 | wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The inherent interest on the origin of genetic novelties can be traced back to Darwin. But it was not until recently that we were allowed to investigate the fundamental process of origin of new genes by the studies on newly evolved Young genes. Two indispensible steps are involved in this process: origin of new gene copies through various mutational mechanisms and evolution of novel functions, which further more leads to fixation of the new copies within populations. The theoretical framework for the former step formed in 1970s. Ohno proposed gene duplication as the most important mechanism producing new gene copies. He also believed that the most common fate for new gene copies is to become pseudogenes. This classical view was validated and was also challenged by the characterization of the first functional young gene jingwei in Drosophila. Recent genome-wide comparison on young genes of Drosophila has elucidated a comprehensive picture addressing remarkable roles of various mechanisms besides gene duplication during origin of new genes. Case surveys revealed it is not rare that new genes Would evolve novel structures and functions to contribute to the adaptive evolution of organisms. Here. we review recent advances in understanding how new genes originated and evolved on the basis of genome-wide results and experimental efforts on cases. We would finally discuss the future directions of this fast-growing research field in the Context of functional genomics era. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a CAS-Max Planck Society Fellowship, an award (No. 30325016) of the National Science Foundation of China (NSFC), two NSFC key grants (No. 30430400 and 30623007), a grant from the National Basic Research Program of China (973 Program) (No. 2007CB815703-5) to W.W., and a NSFC grant (No. 30500283) for junior researchers to S.Y. |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4835]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhou Q,Wang W[*]. On the origin and evolution of new genes-a genomic and experimental perspective[J]. JOURNAL OF GENETICS AND GENOMICS,2008,35(11):639-648. |
| APA | Zhou Q,&Wang W[*].(2008).On the origin and evolution of new genes-a genomic and experimental perspective.JOURNAL OF GENETICS AND GENOMICS,35(11),639-648. |
| MLA | Zhou Q,et al."On the origin and evolution of new genes-a genomic and experimental perspective".JOURNAL OF GENETICS AND GENOMICS 35.11(2008):639-648. |
入库方式： OAI收割
来源：昆明动物研究所
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