Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila
文献类型：期刊论文
| 作者 | Yang SA1,2; Arguello JR3; Li X1,2; Ding Y1,2; Zhou Q1,2; Chen Y4; Zhang Y1; Zhao RP1; Brunet F3; Peng LX1 |
| 刊名 | PLOS GENETICS
 |
| 出版日期 | 2008 |
| 卷号 | 4期号:1页码:e3 |
| ISSN号 | 1553-7390 |
| 通讯作者 | mlong@uchicago.edu ; wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Previous studies of repetitive elements (REs) have implicated a mechanistic role in generating new chimerical genes. Such examples are consistent with the classic model for exon shuffling, which relies on non-homologous recombination. However, recent data for chromosomal aberrations in model organisms suggest that ectopic homology-dependent recombination may also be important. Lack of a dataset comprising experimentally verified young duplicates has hampered an effective examination of these models as well as an investigation of sequence features that mediate the rearrangements. Here we use similar to 7,000 cDNA probes (similar to 112,000 primary images) to screen eight species within the Drosophila melanogaster subgroup and identify 17 duplicates that were generated through ectopic recombination within the last 12 mys. Most of these are functional and have evolved divergent expression patterns and novel chimeric structures. Examination of their flanking sequences revealed an excess of repetitive sequences, with the majority belonging to the transposable element DNAREP1 family, associated with the new genes. Our dataset strongly suggests an important role for REs in the generation of chimeric genes within these species. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a CAS-Max Planck Society Fellowship, a National Natural Science Foundation of China (NSFC) award (number 30325016), a NSFC key grant (number 30430400), and a 973 Program (number 2007CB815703–5) to WW; a US National Science Foundation CAREER award (MCB0238168) and US National Institutes of Health R01 grants (R01GM065429-01A1 and 1R01GM078070-01A1) to ML at the University of Chicago; a Graduate Assistance in Areas of National Need (GAANN) genomics grant supports JRA. |
| 原文出处 | 20084e3.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4845]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Chinese Academy of Sciences (CAS)—Max Planck Junior Research Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Graduate School of Chinese Academy Sciences, Beijing, China 3.Committee on Evolutionary Biology, The University of Chicago, Chicago, Illinois, United States of Americ 4.Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America |
| 推荐引用方式 GB/T 7714 | Yang SA,Arguello JR,Li X,et al. Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila[J]. PLOS GENETICS,2008,4(1):e3. |
| APA | Yang SA.,Arguello JR.,Li X.,Ding Y.,Zhou Q.,...&Wang W[*].(2008).Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila.PLOS GENETICS,4(1),e3. |
| MLA | Yang SA,et al."Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila".PLOS GENETICS 4.1(2008):e3. |
入库方式： OAI收割
来源：昆明动物研究所
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