Evolutionary characteristics of exons expressed at different abundance levels in mammals
文献类型：期刊论文
| 作者 | Yu HJ1; Fang L2; Li X3; Zhang XY1; Ye J2; Li J1; Hu WH1; Zheng BR1; Xiao CJ[*]1 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2009 |
| 卷号 | 54期号:19页码:3546-3554 |
| ISSN号 | 1001-6538 |
| 关键词 | exon evolution sequence identity phastCon Ka/Ks |
| 通讯作者 | cjxiao@public.km.yn.cn |
| 合作状况 | 其它 |
| 英文摘要 | With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms. |
| 学科主题 | Multidisciplinary Sciences |
| 资助信息 | Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project |
| 收录类别 | SCI |
| 原文出处 | 200954193546.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4849]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China 2.Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China 3.CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Yu HJ,Fang L,Li X,et al. Evolutionary characteristics of exons expressed at different abundance levels in mammals[J]. CHINESE SCIENCE BULLETIN,2009,54(19):3546-3554. |
| APA | Yu HJ.,Fang L.,Li X.,Zhang XY.,Ye J.,...&Xiao CJ[*].(2009).Evolutionary characteristics of exons expressed at different abundance levels in mammals.CHINESE SCIENCE BULLETIN,54(19),3546-3554. |
| MLA | Yu HJ,et al."Evolutionary characteristics of exons expressed at different abundance levels in mammals".CHINESE SCIENCE BULLETIN 54.19(2009):3546-3554. |
入库方式： OAI收割
来源：昆明动物研究所
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