Recombination Yet Inefficient Selection along the Drosophila melanogaster Subgroup's Fourth Chromosome
文献类型：期刊论文
| 作者 | Arguello JR[*]1,2; Zhang Y3; Kado T4; Fan CZ2; Zhao RP3; Innan H4; Wang W3; Long MY[*]1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:4页码:848-861 |
| 关键词 | dot chromosome recombination gene conversion selective constraint relaxed constraint purifying selection |
| ISSN号 | 0737-4038 |
| 通讯作者 | jra89@cornell.edu ; mlong@uchicago.edu |
| 合作状况 | 其它 |
| 英文摘要 | A central goal of evolutionary genetics is an understanding of the forces responsible for the observed variation, both within and between species. Theoretical and empirical work have demonstrated that genetic recombination contributes to this variation by breaking down linkage between nucleotide sites, thus allowing them to behave independently and for selective forces to act efficiently on them. The Drosophila fourth chromosome, which is believed to experience no-or very low-rates of recombination has been an important model for investigating these effects. Despite previous efforts, central questions regarding the extent of recombination and the predominant modes of selection acting on it remain open. In order to more comprehensively test hypotheses regarding recombination and its potential influence on selection along the fourth chromosome, we have resequenced regions from most of its genes from Drosophila melanogaster, D. simulans, and D. yakuba. These data, along with available outgroup sequence, demonstrate that recombination is low but significantly greater than zero for the three species. Despite there being recombination, there is strong evidence that its frequency is low enough to have rendered selection relatively inefficient. The signatures of relaxed constraint can be detected at both the level of polymorphism and divergence. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30830021), Chinese Academy of Sciences (KSCX2-YW-G-024), and Ministry of Science (2008AA02Z133, 2010CB529801/05) and by Yunnan Province (0803461101). |
| 原文出处 | 2010274848.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4861]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Committee on Evolutionary Biology, University of Chicago 2.Department of Ecology and Evolution, University of Chicago 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Hayama Center for Advanced Studies, The Graduate University for Advanced Studies, Hayama, Kanagawa, Japan |
| 推荐引用方式 GB/T 7714 | Arguello JR[*],Zhang Y,Kado T,et al. Recombination Yet Inefficient Selection along the Drosophila melanogaster Subgroup's Fourth Chromosome[J]. MOLECULAR BIOLOGY AND EVOLUTION,2010,27(4):848-861. |
| APA | Arguello JR[*].,Zhang Y.,Kado T.,Fan CZ.,Zhao RP.,...&Long MY[*].(2010).Recombination Yet Inefficient Selection along the Drosophila melanogaster Subgroup's Fourth Chromosome.MOLECULAR BIOLOGY AND EVOLUTION,27(4),848-861. |
| MLA | Arguello JR[*],et al."Recombination Yet Inefficient Selection along the Drosophila melanogaster Subgroup's Fourth Chromosome".MOLECULAR BIOLOGY AND EVOLUTION 27.4(2010):848-861. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。