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Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans
文献类型：期刊论文
| 作者 | Zhou Q1,2; Zhu HM3; Huang QF3; Zhao L[*]1; Bachtrog D[*]2; Zhang GJ1,3; Roy SW4; Vicoso B2; Xuan ZL3; Ruan J2 |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:X页码:e109 |
| 关键词 | Drosophila albomicans neo-sex chromosome B chromosome |
| 通讯作者 | zhutom00@gmail.com ; xuanzl@genomics.org.cn ; wangj@genomics.org.cn ; wwang@mail.kiz.ac.cn ; dbachtrog@berkeley.edu |
| 合作状况 | 其它 |
| 英文摘要 | Background: Drosophila albomicans is a unique model organism for studying both sex chromosome and B chromosome evolution. A pair of its autosomes comprising roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only about 0.12 million years ago, thereby creating the youngest and most gene-rich neo-sex system reported to date. This species also possesses recently derived B chromosomes that show non-Mendelian inheritance and significantly influence fertility. Methods: We sequenced male flies with B chromosomes at 124.5-fold genome coverage using next-generation sequencing. To characterize neo-Y specific changes and B chromosome sequences, we also sequenced inbred female flies derived from the same strain but without B's at 28.5-fold. Results: We assembled a female genome and placed 53% of the sequence and 85% of the annotated proteins into specific chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent origin, the non-recombining neo-Y chromosome shows various signs of degeneration, including a significant enrichment of nonfunctional genes compared to the neo-X, and an excess of tandem duplications relative to other chromosomes. We also characterized a B-chromosome linked scaffold that contains an actively transcribed unit and shows sequence similarity to the subcentromeric regions of both the ancient X and the neo-X chromosome. Conclusions: Our results provide novel insights into the very early stages of sex chromosome evolution and B chromosome origination, and suggest an unprecedented connection between the births of these two systems in D. albomicans. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. |
| 语种 | 英语 |
| WOS记录号 | WOS:000304155800001 |
| 公开日期 | 2012-09-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7086]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Department of Integrative Biology, University of California, Berkeley, CA 94720, USA 3.Beijing Genomics Institute-Shenzhen, Shenzhen 518083, China 4.Department of Biology, Stanford University, Palo Alto, CA 94305, USA |
| 推荐引用方式 GB/T 7714 | Zhou Q,Zhu HM,Huang QF,et al. Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans[J]. BMC GENOMICS,2012,13(X):e109. |
| APA | Zhou Q.,Zhu HM.,Huang QF.,Zhao L[*].,Bachtrog D[*].,...&Wang W[*].(2012).Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.BMC GENOMICS,13(X),e109. |
| MLA | Zhou Q,et al."Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans".BMC GENOMICS 13.X(2012):e109. |
入库方式： OAI收割
来源：昆明动物研究所
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