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Association of p53 Arg72Pro polymorphism with bladder cancer: A meta-analysis

文献类型：期刊论文

作者Yang ZL1; Nie SJ4; Zhu H2; Wu XM2; Jia ST2; Luo Y[*]2; Tang WR[*]2,3
刊名GENE
出版日期2013
卷号512期号:2页码:408-413
关键词p53 Meta-analysis Bladder cancer
通讯作者luoyingabc@yahoo.com
合作状况其它
英文摘要Background: p53 tumor suppressor gene Arg72Pro polymorphism has been associated with bladder cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and bladder cancer. 

Methods: Electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. 

Results: The final meta-analysis included 14 published studies with 2176 bladder cancer cases and 2798 controls. The results suggested that the variant genotype was associated with the bladder cancer risk (additive model: OR = 1.72, 95% CI: 1.036-1.325, P = 0.011; dominant model: OR = 1.268, 95% CI: 1.003-1.602, P = 0.047) in Asian subgroup. However, the association was not significant between this polymorphism and bladder cancer risk in Caucasian (additive model: OR = 0.773, 95% CI: 0.564-1.059, P = 0.109; dominant model: OR = 0.685, 95% CI: 0.418-1.124, P = 0.134). 

Conclusion: This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of bladder cancer in Asians. To validate the association between this polymorphism and bladder cancer, further studies with larger participants worldwide are needed.
收录类别SCI
资助信息This work was financially supported by the National Science Foun- dation of China (No. 81101547), the Planned Science and Technology Project of Yunnan Province (2009CA012, 2011DH011), and the Fund of State Key Laboratory of Genetics Resources and Evolution (No. GREKF10-07).
语种英语
WOS记录号WOS:000313768900035
公开日期2013-02-25
源URL[http://159.226.149.42:8088/handle/152453/7145]  
专题昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.School of Life Science, Yunnan University, Kunming, Yunnan, China
2.Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan, 650500, China
3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
4.School of Forensic Medicine, Kunming Medical University, Kunming, China
推荐引用方式
GB/T 7714		 Yang ZL,Nie SJ,Zhu H,et al. Association of p53 Arg72Pro polymorphism with bladder cancer: A meta-analysis[J]. GENE,2013,512(2):408-413.
APA Yang ZL.,Nie SJ.,Zhu H.,Wu XM.,Jia ST.,...&Tang WR[*].(2013).Association of p53 Arg72Pro polymorphism with bladder cancer: A meta-analysis.GENE,512(2),408-413.
MLA Yang ZL,et al."Association of p53 Arg72Pro polymorphism with bladder cancer: A meta-analysis".GENE 512.2(2013):408-413.

入库方式： OAI收割

来源：昆明动物研究所

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