Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors
文献类型：期刊论文
| 作者 | Gou ZH1,2; Wang X1,2; Wang W[*]1 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:E5-6页码:E75−E81 |
| 关键词 | Gamma-aminobutyric acid Glutamate Neurotransmitter Receptor Evolution |
| 通讯作者 | wwang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Gamma-aminobutyric acid (GABA) and glutamate are two important amino acid neurotransmitters widely present in the nervous systems of mammals, insects, round worm, and platyhelminths, while their receptors are quite diversified across different animal phyla. However, the evolutionary mechanisms between the two conserved neurotransmitters and their diversified receptors remain elusive, and antagonistic interactions between GABA and glutamate signal transduction systems, in particular, have begun to attract significant attention. In this review, we summarize the extant results on the origin and evolution of GABA and glutamate, as well as their receptors, and analyze possible evolutionary processes and phylogenetic relationships of various GABAs and glutamate receptors. We further discuss the evolutionary history of Excitatory/Neutral Amino Acid Transporter (EAAT), a transport protein, which plays an important role in the GABA-glutamate “yin and yang” balancedregulation. Finally, based on current advances, we propose several potential directions of future research. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7648]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences (CAS), Kunming 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Gou ZH,Wang X,Wang W[*]. Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors[J]. Zoological Research,2012,33(E5-6):E75−E81. |
| APA | Gou ZH,Wang X,&Wang W[*].(2012).Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors.Zoological Research,33(E5-6),E75−E81. |
| MLA | Gou ZH,et al."Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors".Zoological Research 33.E5-6(2012):E75−E81. |
入库方式： OAI收割
来源：昆明动物研究所
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