Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)
文献类型：期刊论文
| 作者 | Fan YX1,2; Wu RB2; Su R1; Wu JH[*]3,4,6; Dong Y[*]5,6; Li JQ1; Qiao X1; Zhang YJ1; Wang RJ1 |
| 刊名 | GENETICS AND MOLECULAR RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 14期号:4页码:17904-17915 |
| 关键词 | Cashmere goat Gene expression Hair growth cycle Transcriptome |
| 通讯作者 | wujianghonglong@126.com ; loyalyang@163.com |
| 英文摘要 | Previous molecular genetic studies of the goat hair life cycle have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in hair follicle cycle regulation, Illumina sequencing technology was used to catalog differential gene expression profiles in the hair growth cycle (anagen to catagen) of goat, comparing the primary hair follicle with the secondary hair follicle. There were 13,769 and 12,240 unigenes assembled from the reads obtained from primary hair follicle and secondary hair follicle, respectively. Genes encoding keratin proteins and keratin-associated proteins were the most highly expressed. A total of 5899 genes were differentially expressed in anagen vs catagen primary hair follicles, with 532 genes up-regulated and 5367 genes down-regulated. A total of 5208 genes were differentially expressed in anagen vs catagen secondary hair follicle, including 545 genes that were up-regulated and 4663 genes that were down-regulated. Numerous hair growth genes are expressed in the goat hair follicle, of which 73 genes showed co-up-regulation in both hair follicles during the anagen stage. Many of these up-regulated genes, such as STC2, VEGFR, and ROR2, are known to be transfactors in the process of cell differentiation and in the cell cycle. The differential gene expression profiles between primary hair follicles and secondary hair follicles obtained provide a foundation for future studies examining the network of gene expression controlling hair growth cycle in Cashmere goat. |
| 收录类别 | SCI |
| 资助信息 | Research supported by the National “863” Project (#2013AA102506), the National natural Science Foundation of China (#31201773, #31260539, #31272421), and the Excellent Young Scientist Foundation of Inner Mongolia Agricultural University of China (#2014XYQ-1). Also, this research was supported by the Natural Science Foundation of Inner Mongolia (#2013MS0414), the Youth Innovation Foundation of Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences (#2013QNJJM03), and the State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (#GREKF13-02). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10343]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China 2.College of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China 3.Inner Mongolia Prataculture Research Center, Chinese Academy of Science, Hohhot, China 4.Animal Husbandry Institute, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China 5.Kunming University of Science and Technology, Kunming, China 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Fan YX,Wu RB,Su R,et al. Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(4):17904-17915. |
| APA | Fan YX.,Wu RB.,Su R.,Wu JH[*].,Dong Y[*].,...&Wang RJ.(2015).Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus).GENETICS AND MOLECULAR RESEARCH,14(4),17904-17915. |
| MLA | Fan YX,et al."Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)".GENETICS AND MOLECULAR RESEARCH 14.4(2015):17904-17915. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。