Evolution of the human-specific microRNA miR-941
文献类型：期刊论文
| 作者 | Hu HY1; He L1,2; Zhang XY1; Taylor MS3; Tang L1,2; Li J4; Liu JM4; Wang W5; Fominykh K1; Yu HJ[*]4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:X页码:e1145 |
| 通讯作者 | hjyu@ynu.edu.cn ; khaitovich@eva.mpg.de |
| 英文摘要 | MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find that miR-941 emerged de novo in the human lineage, between six and one million years ago, from an evolutionarily volatile tandem repeat sequence. Its copy-number remains polymorphic in humans and shows a trend for decreasing copy-number with migration out of Africa. Emergence of miR-941 was accompanied by accelerated loss of miR-941-binding sites, presumably to escape regulation. We further show that miR-941 is highly expressed in pluripotent cells, repressed upon differentiation and preferentially targets genes in hedgehog- and insulin-signalling pathways, thus suggesting roles in cellular differentiation. Human-specific effects of miR-941 regulation are detectable in the brain and affect genes involved in neurotransmitter signalling. Taken together, these results implicate miR-941 in human evolution, and provide an example of rapid regulatory evolution in the human linage. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Natural Science Foundation of China (31171232), from CAS Key Directional Program (KSCX2-EW-R-02-02, KSCX2-EW-J-15) and from Ministry of Science and Technology, P.R.China (S2012GR0095) to P.K., and grants from National Natural Science Foundation of China (30871342, 31171215) to H.Y. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10372]  |
| 专题 | 昆明动物研究所_基因起源组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai 200031, China 2.Graduate School of Chinese Academy of Sciences, 19 Yuquan Road, 100039 Beijing, China 3.MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK 4.The School of Life Sciences and Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 5.State Key Laboratory of Evolution and Genetic Resources, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 6.Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany 7.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany |
| 推荐引用方式 GB/T 7714 | Hu HY,He L,Zhang XY,et al. Evolution of the human-specific microRNA miR-941[J]. NATURE COMMUNICATIONS,2012,3(X):e1145. |
| APA | Hu HY.,He L.,Zhang XY.,Taylor MS.,Tang L.,...&Guo S.(2012).Evolution of the human-specific microRNA miR-941.NATURE COMMUNICATIONS,3(X),e1145. |
| MLA | Hu HY,et al."Evolution of the human-specific microRNA miR-941".NATURE COMMUNICATIONS 3.X(2012):e1145. |
入库方式： OAI收割
来源：昆明动物研究所
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