PATTERNED HIGH-FREQUENCY STIMULATION INDUCES A FORM OF LONG-TERM DEPRESSION DEPENDENT ON GABAA AND mACh RECEPTORS IN THE HIPPOCAMPUS
文献类型：期刊论文
| 作者 | Zhu YY1,2; Jing L1; Duan TT1,2; Yuan Q1; Cao J1; Zhou QX[*]1; Xu L[*]1,2 |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 250期号:X页码:658-663 |
| 关键词 | hippocampal CA1 long-term depression GABA(A) receptors mACh receptors |
| 通讯作者 | qixin_zhou@126.com ; lxu@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus |
| 收录类别 | SCI |
| 资助信息 | This work was sup- ported by 973 program from the Ministry of Science and Technology of China (2013CB835103 and 2009CB941302 to L.X., 2009CB522006 to J.C.), NSFC-CIHR Joint Grant (81168820536 to L.X.), National Natural Science Foundation of China (31100775 to Q.-X.Z.) and Strategic Priority Research Program of CAS (XDB0202 to L.X.). |
| 语种 | 英语 |
| 公开日期 | 2014-09-26 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8014]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.School of Life Sciences, University of Science and Technology of China, Hefei 230027, China |
| 推荐引用方式 GB/T 7714 | Zhu YY,Jing L,Duan TT,et al. PATTERNED HIGH-FREQUENCY STIMULATION INDUCES A FORM OF LONG-TERM DEPRESSION DEPENDENT ON GABAA AND mACh RECEPTORS IN THE HIPPOCAMPUS[J]. NEUROSCIENCE,2013,250(X):658-663. |
| APA | Zhu YY.,Jing L.,Duan TT.,Yuan Q.,Cao J.,...&Xu L[*].(2013).PATTERNED HIGH-FREQUENCY STIMULATION INDUCES A FORM OF LONG-TERM DEPRESSION DEPENDENT ON GABAA AND mACh RECEPTORS IN THE HIPPOCAMPUS.NEUROSCIENCE,250(X),658-663. |
| MLA | Zhu YY,et al."PATTERNED HIGH-FREQUENCY STIMULATION INDUCES A FORM OF LONG-TERM DEPRESSION DEPENDENT ON GABAA AND mACh RECEPTORS IN THE HIPPOCAMPUS".NEUROSCIENCE 250.X(2013):658-663. |
入库方式： OAI收割
来源：昆明动物研究所
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