Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome
文献类型：期刊论文
| 作者 | Ma ZS[*]1; Li LW1; Li WD[1; Li J1; Chen HJ2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e28048 |
| 通讯作者 | samma@uidaho.edu |
| 合作状况 | 其它 |
| 英文摘要 | We aim to investigate the effects of Hodgkin's lymphoma and the chemotherapy for treating the disease on the human milk microbiome through integrated network and community diversity analyses. Our analyses suggest that Hodgkin's lymphoma seems to have a suppressing effect on the milk microbiome by lowering the milk microbial community diversity, as measured by the Hill numbers profiles. Although the diversity analysis did not reveal an effect of chemotherapy on community diversity, bacterial species interaction network analysis shows that chemotherapy may help to slightly restore the milk microbiome impacted by Hodgkin's lymphoma through its influence on the interactions among species (or OTUs). We further constructed diversity-metabolites network, which suggests that the milk microbial diversity is positively correlated with some beneficial milk metabolites such as DHA (DocosaHexaenoic Acid), and that the diversity is negatively correlated with some potentially harmful metabolites such as Butanal. We hence postulate that higher milk microbial diversity should be a signature of healthy mothers and beneficial to infants. Finally, we constructed metabolites OTU correlation networks, from which we identified some special OTUs. These OTUs deserve further investigations given their apparent involvements in regulating the levels of critical milk metabolites such as DHA, Inositol and Butanal. |
| 收录类别 | SCI |
| 资助信息 | This research received funding from the following sources: National Science Foundation of China (Grants No. 61175071, 71473243), “The Exceptional Scientists Program and Top Oversea Scholars Program” of Yunnan Province. The research also received funding from an open grant (GREKF13-11) from the State Key Laboratory of Genetic Resources and Evolution. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10276]  |
| 专题 | 昆明动物研究所_计算生物与生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Computational Biology and Medical Ecology Lab, State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650023, China. 2.College of Mathematics, Honghe University, Mengzi, Yunnan 661100, China |
| 推荐引用方式 GB/T 7714 | Ma ZS[*],Li LW,Li WD[,et al. Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome[J]. SCIENTIFIC REPORTS,2016,6(X):e28048. |
| APA | Ma ZS[*],Li LW,Li WD[,Li J,&Chen HJ.(2016).Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome.SCIENTIFIC REPORTS,6(X),e28048. |
| MLA | Ma ZS[*],et al."Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome".SCIENTIFIC REPORTS 6.X(2016):e28048. |
入库方式： OAI收割
来源：昆明动物研究所
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