Methylation and gene mutation in eukaryotic DNA
文献类型：期刊论文
| 作者 | Liu CQ1; Huang JF[*]1; Wang J1; Liu WB2 |
| 刊名 | ACTA BIOLOGICA HUNGARICA
 |
| 出版日期 | 1998 |
| 卷号 | 49期号:2-4页码:185-191 |
| 关键词 | DNA methylation 5-methylcytosine deamination gene mutation molecular electrostatic potential |
| ISSN号 | 0236-5383 |
| 通讯作者 | tbrg@public.km.yn.cn |
| 合作状况 | 其它 |
| 英文摘要 | 5-methylcytosine (m(5)C) as a rare base exists in eukaryotic genomes, which is a normal constitution in many eukaryotic DNA and the existence of m(5)C is a feature of eukaryotic DNA. Under regular physiological conditions, cytosine of eukaryotic DNA is usually methylated. Up to the present, many people consider that the m(5)C may be mutation hotspots by the deamination leading to gene mutation. Our study indicated that the spontaneous mutation caused by the transition of G.C --> A.T, in eukaryotic DNA, may result from the tautomer changing of base pairs and may also be cause by other factor actions, however it could not be caused by the deamination of m(5)C. |
| 学科主题 | Biology |
| 收录类别 | SCI |
| 原文出处 | 199849185.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4877]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming, Yunnan, Peoples R China 2.Yunnan Univ, Modern Biol Ctr, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu CQ,Huang JF[*],Wang J,et al. Methylation and gene mutation in eukaryotic DNA[J]. ACTA BIOLOGICA HUNGARICA,1998,49(2-4):185-191. |
| APA | Liu CQ,Huang JF[*],Wang J,&Liu WB.(1998).Methylation and gene mutation in eukaryotic DNA.ACTA BIOLOGICA HUNGARICA,49(2-4),185-191. |
| MLA | Liu CQ,et al."Methylation and gene mutation in eukaryotic DNA".ACTA BIOLOGICA HUNGARICA 49.2-4(1998):185-191. |
入库方式： OAI收割
来源：昆明动物研究所
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