Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples
文献类型：期刊论文
| 作者 | Zhang SX1,2; Wang X1; Chen XF3; Cao H1; Zhang W4; Liu CQ[*]1,5,6 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2008 |
| 卷号 | 53期号:3页码:377-383 |
| 关键词 | avian influenza (AI) hemagglutinin (HA) cleavage site RNA secondary structure dynamic extended folding |
| ISSN号 | 1001-6538 |
| 通讯作者 | liucq@ynu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Here we report the codon bias and the mRNA secondary structural features of the hemagglutinin (HA) cleavage site basic amino acid regions of avian influenza virus H5N1 subtypes. We have developed a dynamic extended folding strategy to predict RNA secondary structure with RNAstructure 4.1 program in an iterative extension process. Statistical analysis of the sequences showed that the HA cleavage site basic amino acids favor the adenine-rich codons, and the corresponding mRNA fragments are mainly in the folding states of single-stranded loops. Our sequential and structural analyses showed that to prevent and control these highly pathogenic viruses, that is, to inhibit the gene expression of avian influenza virus H5N1 subtypes, we should consider the single-stranded loop regions of the HA cleavage site-coding sequences as the targets of RNA interference. |
| 收录类别 | SCI |
| 资助信息 | Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) |
| 原文出处 | 200853377.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4907]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Modern Biological Research Center, Yunnan University, Kunming 650091, China 2.Henan Medical School, Kaifeng 475300, China 3.Tangdu Hospital, Fourth Military Medical University, Xi’an 710033, China 4.Deparment of Cell Biology and Medical Genetics, Kunming Medical College, Kunming 650031, China 5.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 6.Center for Theoretical Biology, Peking University, Beijing 100871, China |
| 推荐引用方式 GB/T 7714 | Zhang SX,Wang X,Chen XF,et al. Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples[J]. CHINESE SCIENCE BULLETIN,2008,53(3):377-383. |
| APA | Zhang SX,Wang X,Chen XF,Cao H,Zhang W,&Liu CQ[*].(2008).Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples.CHINESE SCIENCE BULLETIN,53(3),377-383. |
| MLA | Zhang SX,et al."Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples".CHINESE SCIENCE BULLETIN 53.3(2008):377-383. |
入库方式： OAI收割
来源：昆明动物研究所
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