Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships
文献类型：期刊论文
| 作者 | Yang J1; Liu CQ[*]1,2 |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
 |
| 出版日期 | 2000 |
| 卷号 | 532期号:X页码:1-10 |
| 关键词 | interleukin molecular modeling sharing the common gamma chain of IL-2R interaction |
| ISSN号 | 0166-1280 |
| 通讯作者 | jfhuang@public.km.yn.cn |
| 合作状况 | 其它 |
| 英文摘要 | Five models for human interleukin-7 (HIL-7), HIL-9, HIL-13, HIL-15 and HIL-17 have been generated by SYBYL software package. The primary models were optimized using molecular dynamics and molecular mechanics methods. The final models were optimized using a steepest descent algorithm and a subsequent conjugate gradient method. The complexes with these interleukins and the common gamma chain of interleukin-2 receptor (IL-2R) were constructed and subjected to energy minimization. We found residues, such as Gln127 and Tyr103, of the common gamma chain of IL-2R are very important. Other residues, e.g. Lys70, Asn128 and Glu162, are also significant. Four hydrophobic grooves and two hydrophilic sites converge at the active site triad of the gamma chain. The binding sites of these interleukins interaction with the common gamma chain exist in the first helical and/or the fourth helical domains. Therefore, we conclude that these interleukins binds to the common gamma chain of IL-2R by the first and the fourth helix domain. Especially at the binding sites of some residues (lysine, arginine, asparagine, glutamic acid and aspartic acid), with a discontinuous region of the common gamma chain of IL-2R, termed the interleukins binding sites (103-210). The study of these sites can be important for the development of new drugs. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China, No.39770418 |
| 原文出处 | 20005321.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5163]  |
| 专题 | 昆明动物研究所_其他 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cell and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming YN650223, People’s Republic of China 2.Modern Biological Center, Yunnan University, Kunming YN650091, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yang J,Liu CQ[*]. Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2000,532(X):1-10. |
| APA | Yang J,&Liu CQ[*].(2000).Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,532(X),1-10. |
| MLA | Yang J,et al."Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 532.X(2000):1-10. |
入库方式： OAI收割
来源：昆明动物研究所
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