Interaction between human interleukin-16 and CD4 receptor of HIV-1
文献类型：期刊论文
| 作者 | Yang J1; Liu CQ[*]1,2 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000 |
| 卷号 | 21期号:6页码:547-553 |
| 关键词 | molecular structure interleukin-16 CD4 antigens computer-aided design protein conformation |
| ISSN号 | 0253-9756 |
| 其他题名 | 人白介素16与HIV-1的CD4受体的相互作用 |
| 通讯作者 | tbrg@public.km.yn.cn |
| 合作状况 | 其它 |
| 中文摘要 | 目的:研究人白介素-16和HIV-1病毒受体CD4(T淋巴细胞分化抗原)的作用机理。方法:人白介素-16的结构保守区由SYBYL软件中的Biopolymer模块建立,其非保守区由LOOP SEARCH方法建立。结果:人白介素-16首先形成二聚体,然后与CD4的二聚体进一步形成HIL-16与CD4的复合物二聚体。接着,该复合物二聚体通过二硫键(Cys31-Cys31)形成HIL-16与CD4复合物的四聚体。结论:该相互作用模型有助于推测白介素-16的作用机制,也有益于全新抗艾滋病药物的合理设计。 |
| 英文摘要 | AIM: To study the interaction between human interleukin-16 (IL-16) and the receptor CD4 (T-lymphocyte differentiation antigen) of human immunodeficiency virus type 1 (HIV-1). METHODS: Two structurally con served regions (SCRs) of human IL-16 were built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of human interleukin-1 (HIL-4) and HIL-2 as the templates. The coordinates for amino-terminal residue sequence, carboxyl-terminal residue sequences, and cytoplasm loops were generated using Biopolymer's LOOP SEARCH algorithm. RESULTS: HIL-16 first formed a homodimer, then contacted with CD4 dimer further forming a dimeric complex. Subsequently, the dimeric complex constructed the tetrameric complex by two disulfide bridges between the cysteines of HIL-16 (Cys31-Cys31). CONCLUSION: The interaction model is useful to propose the action mechanism of HIL-16 and is beneficial for rational designing of novel anti-HIV drugs. |
| 收录类别 | 其他 |
| 资助信息 | Project supported by the National Natural Science Foundation of China, № 39770418 |
| 原文出处 | 200021547.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5167]  |
| 专题 | 昆明动物研究所_其他 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.CAS, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming 650223, Peoples R China 2.Yunnan Univ, Mod Biol Ctr, Kunming 650091, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang J,Liu CQ[*]. Interaction between human interleukin-16 and CD4 receptor of HIV-1[J]. ACTA PHARMACOLOGICA SINICA,2000,21(6):547-553. |
| APA | Yang J,&Liu CQ[*].(2000).Interaction between human interleukin-16 and CD4 receptor of HIV-1.ACTA PHARMACOLOGICA SINICA,21(6),547-553. |
| MLA | Yang J,et al."Interaction between human interleukin-16 and CD4 receptor of HIV-1".ACTA PHARMACOLOGICA SINICA 21.6(2000):547-553. |
入库方式： OAI收割
来源：昆明动物研究所
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