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Statistical correlation between protein secondary structure and messenger RNA stem-loop structure

文献类型：期刊论文

作者Jia MW1,2; Luo LF[*]1,2,3; Liu CQ2
刊名BIOPOLYMERS
出版日期2004
卷号73期号:1页码:16-26
关键词protein secondary structure stem/loop sequence-structure database statistical correlation
ISSN号0006-3525
通讯作者lfluo@mail.imu.edu.cn
合作状况其它
英文摘要Anew integrated sequence-structure database, called IADE (Integrated ASTRAL-DSSP-EMBL), incorporating matching mRNA sequence, amino acid sequence, and protein secondary structural data, is constructed. It includes 648 protein domains. Based on the IADE database, we studied the relation between RNA stem-loop frequencies and protein secondary structure. It was found that the alpha-helices and beta-strands on proteins tend to be preferably "coded" by mRNA stem region, while the coils on proteins tend to be preferably "coded" by mRNA loop region. These tendencies are more obvious if we observe the structural words (SWs). An SW is defined by a four-amino-acid-fragment that shows the pronounced secondary structural (alpha-helix or beta-strand) propensity. It is demonstrated that the deduced correlation between protein and mRNA structure can hardly be explained as the stochastic fluctuation effect.
收录类别SCI
资助信息National Science Foundation of China (NSFC) and Kunming Institute of Zoology
原文出处20047316.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5331]  
专题昆明动物研究所_结构生物信息学
作者单位1.Inner Mongolia Univ, Dept Phys, Hohhot 010021, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650023, Peoples R China
3.Center for Theoretical Biology, Peking University, Beijing 100871, China
推荐引用方式
GB/T 7714		 Jia MW,Luo LF[*],Liu CQ. Statistical correlation between protein secondary structure and messenger RNA stem-loop structure[J]. BIOPOLYMERS,2004,73(1):16-26.
APA Jia MW,Luo LF[*],&Liu CQ.(2004).Statistical correlation between protein secondary structure and messenger RNA stem-loop structure.BIOPOLYMERS,73(1),16-26.
MLA Jia MW,et al."Statistical correlation between protein secondary structure and messenger RNA stem-loop structure".BIOPOLYMERS 73.1(2004):16-26.

入库方式： OAI收割

来源：昆明动物研究所

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