The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network
文献类型：期刊论文
| 作者 | Yu Q1; Huang JF[*]1,2 |
| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2012 |
| 卷号 | 9期号:4页码:426-430 |
| 关键词 | Drug targets Topological similarity Protein-protein interaction |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Drug target proteins (DTPs) are mainly distributed in several druggable families. Although proteins in one druggable family are similar in sequence and structure, not all of them are DTPs. However, the difference between DTPs and potential target proteins (PTPs) is not yet clear. We explored the topological difference between DTPs and PTPs in the human protein-protein interaction (PPI) network. Hence we found DTPs exhibited patterns of topological similarity in the human PPI network. Moreover, we hypothesize that DTPs perturb the network in a controlled manner because their influences on the PPI network were greater than PTPs' but less than hubs'. At last, we applied the similarity of topological features to prioritize PTPs in two largest families. These results demonstrated the potential application of topological features, which could be helpful to find new DTP candidates. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300) for JFH. |
| 语种 | 英语 |
| 公开日期 | 2012-09-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7021]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming Institute of Zoology-Chinese University of Hongkong Joint Research Center for Bio-resources and Human Disease Mechanisms, Kunming 650223, P.R. China |
| 推荐引用方式 GB/T 7714 | Yu Q,Huang JF[*]. The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2012,9(4):426-430. |
| APA | Yu Q,&Huang JF[*].(2012).The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network.LETTERS IN DRUG DESIGN & DISCOVERY,9(4),426-430. |
| MLA | Yu Q,et al."The Analysis of the Druggable Families Based on Topological Features in the Protein-Protein Interaction Network".LETTERS IN DRUG DESIGN & DISCOVERY 9.4(2012):426-430. |
入库方式： OAI收割
来源：昆明动物研究所
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