Comparative systems biology between human and animal models based on next-generation sequencing methods
文献类型：期刊论文
| 作者 | Zhao YQ1; Li GH1; Huang JF[*]1,2 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:E2页码:E35−E41 |
| 关键词 | Animal models Animal models Comparative systems biology Comparative systems biology Next-generation sequencing RNA-seq ChIP-seq |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as “comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels”. Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (31123005), the Chinese Academy of Sciences (Y002731071), and the National Basic Research Program of China (2009CB941300) |
| 语种 | 英语 |
| 公开日期 | 2013-06-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7481]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhao YQ,Li GH,Huang JF[*]. Comparative systems biology between human and animal models based on next-generation sequencing methods[J]. Zoological Research,2013,34(E2):E35−E41. |
| APA | Zhao YQ,Li GH,&Huang JF[*].(2013).Comparative systems biology between human and animal models based on next-generation sequencing methods.Zoological Research,34(E2),E35−E41. |
| MLA | Zhao YQ,et al."Comparative systems biology between human and animal models based on next-generation sequencing methods".Zoological Research 34.E2(2013):E35−E41. |
入库方式： OAI收割
来源：昆明动物研究所
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