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Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex
文献类型：期刊论文
| 作者 | Wang JW2; Zhao YQ1; Wang YJ3; Huang JF[*]1,4 |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 587期号:2页码:136-141 |
| 关键词 | Inter-protein coevolution Oncogenic mutations Melanoma Molecular dynamics simulation CDK6-CDKN2A complex |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Coevolution between proteins is crucial for understanding protein-protein interaction. Simultaneous changes allow a protein complex to maintain its overall structural-functional integrity. In this study, we combined statistical coupling analysis (SCA) and molecular dynamics simulations on the CDK6-CDKN2A protein complex to evaluate coevolution between proteins. We reconstructed an inter-protein residue coevolution network, consisting of 37 residues and 37 interactions. It shows that most of the coevolved residue pairs are spatially proximal. When the mutations happened, the stable local structures were broken up and thus the protein interaction was decreased or inhibited, with a following increased risk of melanoma. The identification of inter-protein coevolved residues in the CDK6-CDKN2A complex can be helpful for designing protein engineering experiments |
| 资助信息 | This work was supported by the National Natural Science Foun- dation of China (Grant No. 31123005), Chinese Academy of Sci- ences (Grant No. Y002731071), and the National Basic Research Program of China (Grant No. 2009CB941300). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313635400005 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7664]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Eastern Jiaochang Road, Kunming, Yunnan 650223, China 2.Yantai Yuhuangding Hospital, Yantai, Shandong Province 264000, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Kunming Institute of Zoology, Chinese University of Hongkong, Joint Research Center for Bio-resources and Human Disease Mechanisms, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Wang JW,Zhao YQ,Wang YJ,et al. Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex[J]. FEBS LETTERS,2013,587(2):136-141. |
| APA | Wang JW,Zhao YQ,Wang YJ,&Huang JF[*].(2013).Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex.FEBS LETTERS,587(2),136-141. |
| MLA | Wang JW,et al."Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex".FEBS LETTERS 587.2(2013):136-141. |
入库方式： OAI收割
来源：昆明动物研究所
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