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The characterization and comparison of amyloidogenic segments and non-amyloidogenic segments shed light on amyloid formation

文献类型：期刊论文

作者Chen SM1,2; Gao S3; Cheng DQ1,2; Huang JF[*]1,4
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2014
卷号447期号:2页码:255-262
关键词Amyloid Amyloidogenic segments Flexibility Non-amyloidogenic segments Physico-chemical properties
通讯作者huangjf@mail.kiz.ac.cn
合作状况其它
英文摘要Amyloid fibrillar aggregates of proteins or peptides are involved in the etiology of several neurodegenerative diseases and represent a major problem in healthcare. Short regions in the protein trigger this aggregation. It is important to understand the basis of such short regions aggregation and amyloidosis for therapeutic intervention. In this study, we describe specific physico-chemical properties of amyloidogenic segments and compare them with non-amyloidogenic segments. First, amyloidogenic segments are characterized by lower values for average net charge, electrostatic potential, solvent accessible surface area and B-factor when compared to the non-amyloidogenic segments of the same proteins. Second, they are enriched in hydrophobic residues and have a tendency to form hydrogen bonds. Thus, amyloidogenic segments have distinct physico-chemical properties that are different from those of non-amyloidogenic segments. Third, and quite unexpectedly, our dynamic simulation studies support the hypothesis that amyloidogenic segments have lower average flexibility than non-amyloidogenic segments. Furthermore, the presence of amyloidogenic segments in disordered proteins does not contradict the observation that amyloidogenic segments are less flexible.
资助信息This work was supported by the National Basic Research Pro- gram of China (grant number 2013CB835100), and the National Natural Science Foundation of China (grant number 31123005 to J.F.H.).
收录类别SCI
语种英语
WOS记录号WOS:000336510900007
公开日期2014-06-04
源URL[http://159.226.149.42:8088/handle/152453/7871]  
专题昆明动物研究所_结构生物信息学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32, Eastern Jiaochang Road, Kunming, Yunnan 650223, China
2.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China
3.Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
4.Kunming Institute of Zoology – Chinese University of Hongkong Joint Research Center for Bio-Resources and Human Disease Mechanisms, Kunming 650223, China
推荐引用方式
GB/T 7714		 Chen SM,Gao S,Cheng DQ,et al. The characterization and comparison of amyloidogenic segments and non-amyloidogenic segments shed light on amyloid formation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,447(2):255-262.
APA Chen SM,Gao S,Cheng DQ,&Huang JF[*].(2014).The characterization and comparison of amyloidogenic segments and non-amyloidogenic segments shed light on amyloid formation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,447(2),255-262.
MLA Chen SM,et al."The characterization and comparison of amyloidogenic segments and non-amyloidogenic segments shed light on amyloid formation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447.2(2014):255-262.

入库方式： OAI收割

来源：昆明动物研究所

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