Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency
文献类型：期刊论文
| 作者 | Li WX1,2; Dai SX2; Zheng JJ2; Liu JQ2; Huang JF[*]2,3,4 |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:8页码:6670–6687 |
| 关键词 | MTHFR C677T MTHFR A1298C MTR A2756G MTRR A66G folate deficiency |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive population. A total of 480 subjects aged 28-75 were enrolled in this study from September 2005-December 2005 from six hospitals in different Chinese regions. Known genotypes were detected by PCR-RFLP methods and serum folate was measured by chemiluminescence immunoassay. Our results showed that MTHFR 677TT and MTR 2756AG + GG were independently associated with a higher risk of folate deficiency (TT vs. CC + CT, p < 0.001 and AG + GG vs. AA p = 0.030, respectively). However, the MTHFR A1298C mutation may confer protection by elevating the serum folate level (p = 0.025). Furthermore, patients carrying two or more risk genotypes showed higher odds of folate deficiency than null risk genotype carriers, especially those carrying four risk genotypes. These findings were verified by generalized multifactor dimensionality reduction (p = 0.0107) and a cumulative effects model (p = 0.001). The results of this study have shown that interactions among homocysteine metabolism gene polymorphisms lead to dramatic elevations in the folate deficiency risk |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100) , and the National Natural Science Foundation of China (Grant No. 31123005 and No. 31401142). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and for their helpful advice on data analysis. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9377]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Institute of Health Sciences, Anhui University, Hefei 230601, Anhui, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Kunming 650223, Yunnan, China 4.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li WX,Dai SX,Zheng JJ,et al. Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency[J]. NUTRIENTS,2015,7(8):6670–6687. |
| APA | Li WX,Dai SX,Zheng JJ,Liu JQ,&Huang JF[*].(2015).Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency.NUTRIENTS,7(8),6670–6687. |
| MLA | Li WX,et al."Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency".NUTRIENTS 7.8(2015):6670–6687. |
入库方式： OAI收割
来源：昆明动物研究所
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