Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts
文献类型：期刊论文
| 作者 | Guo YC1,2; Zhang LQ2,3; Li GH[*]2; Huang JF[*]2; Dai SX2; Li WX2,4; Zheng JJ2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:5页码:e0155140 |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 英文摘要 | Dekkera yeasts have often been considered as alternative sources of ethanol production that could compete with S. cerevisiae. The two lineages of yeasts independently evolved traits that include high glucose and ethanol tolerance, aerobic fermentation, and a rapid ethanol fermentation rate. The Saccharomyces yeasts attained these traits mainly through whole genome duplication approximately 100 million years ago (Mya). However, the Dekkera yeasts, which were separated from S. cerevisiae approximately 200 Mya, did not undergo whole genome duplication (WGD) but still occupy a niche similar to S. cerevisiae. Upon analysis of two Dekkera yeasts and five closely related non-WGD yeasts, we found that a massive loss of cis-regulatory elements occurred in an ancestor of the Dekkera yeasts, which led to improved mitochondrial functions similar to the S. cerevisiae yeasts. The evolutionary analysis indicated that genes involved in the transcription and translation process exhibited faster evolution in the Dekkera yeasts. We detected 90 positively selected genes, suggesting that the Dekkera yeasts evolved an efficient translation system to facilitate adaptive evolution. Moreover, we identified that 12 vacuolar H+-ATPase (V-ATPase) function genes that were under positive selection, which assists in developing tolerance to high alcohol and high sugar stress. We also revealed that the enzyme PGK1 is responsible for the increased rate of glycolysis in the Dekkera yeasts. These results provide important insights to understand the independent adaptive evolution of the Dekkera yeasts and provide tools for genetic modification promoting industrial usage. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to JFH, No. 31401142 to SXD and NO. 31401137 to GHL). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9790]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China. 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Graduate School of Life Science, Tohoku University, Sendai, Miyagi, Japan 4.Institute of Health Sciences, Anhui University, Hefei, Anhui, China |
| 推荐引用方式 GB/T 7714 | Guo YC,Zhang LQ,Li GH[*],et al. Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts[J]. PLOS ONE,2016,11(5):e0155140. |
| APA | Guo YC.,Zhang LQ.,Li GH[*].,Huang JF[*].,Dai SX.,...&Zheng JJ.(2016).Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts.PLOS ONE,11(5),e0155140. |
| MLA | Guo YC,et al."Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts".PLOS ONE 11.5(2016):e0155140. |
入库方式： OAI收割
来源：昆明动物研究所
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