Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia
文献类型：期刊论文
| 作者 | Ma L1,2; Wu DD3; Ma SL4; Tan LW5; Chen XG5; Tang NLS[*]6,7,8; Yao YG[*]1,2,5 |
| 刊名 | JOURNAL OF PSYCHIATRIC RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 57期号:X页码:84-89 |
| 关键词 | Association CREB1 signal pathway Positive selection Schizophrenia |
| 通讯作者 | nelsontang@cuhk.edu.hk ; yaoyg@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | CREB1 is a cAMP responsive transcriptional factor which plays a key role in neural development. CREB1 signal pathway (CSP) has been implicated repeatedly in studies of predisposition for schizophrenia. We speculated that CSP has undergone positive selection during evolution of modern human and some genes that have undergone natural selection in the past may predispose to schizophrenia (SCZ) in modern time. Positive selection and association analysis were employed to explore the molecular evolution of CSP and association with schizophrenia. Our results showed a pan-ethnic selection event on NRG1 and CREB1, as confirmed in all 14 ethnic populations studied, which also suggested a selection process occurred before the "Out of Africa" scenario. Analysis of 62 SNPs covering 6 CSP genes in 2019 Han Chinese (976 SCZ patients and 1043 healthy individuals) showed an association of two SNPs (rs4379857, P = 0.009, OR [95% CI]: 1.200 [1.379-1.046]; rs2238751, P = 0.023, OR [95% CI]: 1.253 [1.522-1.032]) with SCZ. However, none of these significances survived after multiple testing corrections. Nonetheless, we observed an association of a rare CREB1 haplotype CCGGC (Bonferroni corrected P = 1.74 x 10(-5)) with SCZ. Our study showed that there was substantial population heterogeneity in genetic predisposition to SCZ, and different genes in the CSP pathway may predispose to SCZ in different populations. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020300). |
| 语种 | 英语 |
| WOS记录号 | WOS:000341550100010 |
| 公开日期 | 2014-08-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7989]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650201, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China 5.Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 6.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan, China 7.Department of Chemical Pathology and Laboratory of Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China 8.Functional Genomics and Biostatistical Computing Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China |
| 推荐引用方式 GB/T 7714 | Ma L,Wu DD,Ma SL,et al. Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2014,57(X):84-89. |
| APA | Ma L.,Wu DD.,Ma SL.,Tan LW.,Chen XG.,...&Yao YG[*].(2014).Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia.JOURNAL OF PSYCHIATRIC RESEARCH,57(X),84-89. |
| MLA | Ma L,et al."Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia".JOURNAL OF PSYCHIATRIC RESEARCH 57.X(2014):84-89. |
入库方式： OAI收割
来源：昆明动物研究所
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