Molecular and evolutionary analyses of formyl peptide receptors suggest the absence of VNO-specific FPRs in primates
文献类型：期刊论文
| 作者 | Yang H; Shi P[*] |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2010 |
| 卷号 | 37期号:12页码:771-778 |
| 关键词 | formyl peptide receptor vomeronasal chemosensory receptor primates |
| 通讯作者 | shipengsir@gmail.com |
| 合作状况 | 其它 |
| 中文摘要 | Formyl peptide receptors (FPRs) were observed to expand in rodents and were recently suggested as candidate vomeronasal chemosensory receptors. Since vomeronasal chemosensory receptors usually underwent positive selection and evolved concordantly with the vomeronasal organ (VNO) morphology, we surveyed FPRs in primates in which VNO morphology is greatly diverse and thus it would provide us a clearer view of VNO-FPRs evolution. By screening available primate genome sequences, we obtained the FPR repertoires in representative primate species. As a result, we did not find FPR family size expansion in primates. Further analyses showed no evolutionary force variance between primates with or without VNO structure, which indicated that there was no functional divergence among primates FPRs. Our results suggest that primates lack the VNO-specific FPRs and the FPR expansion is not a common phenomenon in mammals outside rodent lineage, regardless of VNO complexity. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Nat- ural Science Foundation of China (No. 30900793) and West Light Foundation of the Chinese Academy of Sci- ences to H.Y., and by a start-up fund of “Hundreds Talent Program” from Chinese Academy of Sciences and a grant from Key Project from National Natural Science Founda- tion of China (No. 30930015) to P.S. |
| 语种 | 英语 |
| 公开日期 | 2011-03-14 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6568]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Yang H,Shi P[*]. Molecular and evolutionary analyses of formyl peptide receptors suggest the absence of VNO-specific FPRs in primates[J]. JOURNAL OF GENETICS AND GENOMICS,2010,37(12):771-778. |
| APA | Yang H,&Shi P[*].(2010).Molecular and evolutionary analyses of formyl peptide receptors suggest the absence of VNO-specific FPRs in primates.JOURNAL OF GENETICS AND GENOMICS,37(12),771-778. |
| MLA | Yang H,et al."Molecular and evolutionary analyses of formyl peptide receptors suggest the absence of VNO-specific FPRs in primates".JOURNAL OF GENETICS AND GENOMICS 37.12(2010):771-778. |
入库方式： OAI收割
来源：昆明动物研究所
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