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Diversified pattern of the human colorectal cancer microbiome
文献类型：期刊论文
| 作者 | Geng JW1,2; Fan H1; Tang XD1; Zhai HQ1; Zhang ZG[*]2 |
| 刊名 | GUT PATHOGENS
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:X页码:e2 |
| 关键词 | Chinese CRC Microbiome Pyrosequencing |
| 通讯作者 | zhangzhigang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: The aim of this study is to expand existing knowledge about the CRC-associated microbiome among Han Chinese, and to further discover the variation pattern of the human CRC microbiome across all population. Findings: Using pyrosequencing-based molecular monitoring of bacterial 16S rRNA gene from eight tumor/normal tissue pairs of eight Chinese CRC patients, we analyzed and characterized the basic features of the CRC-associated microbiome. Firstly, we discovered an increasing diversity among tumor-associated bacterial communities. Secondly, in 50% of Chinese CRC patients, we found a significant increase of Roseburia (P = 0.017), and a concurrent decrease of both Microbacterium (P = 0.009) and Anoxybacillus (P = 0.009) in tumor tissue. Conclusions: We discovered a novel CRC microbiome pattern in Chinese. Both the over-represented Roseburia bacteria at tumor sites and the over-represented Microbacterium and Anoxybacillus bacteria away from tumor sites were both closely related in Chinese CRC patients. Across several populations reported in this study and previously, we observed both common and distinctive patterns of human CRC microbiome's association with a high-risk of CRC. |
| 收录类别 | SCI |
| 资助信息 | This research was supported by grants from Natural Science Foundation of Yunnan Province of China (Grant No. 2010CD191 and Grant No. 2011FA035) and from National Natural Science Foundation of China (NSFC) (Grant No. 31100916). |
| 语种 | 英语 |
| WOS记录号 | WOS:000315940400001 |
| 公开日期 | 2013-04-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7289]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming 650032, China. 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Geng JW,Fan H,Tang XD,et al. Diversified pattern of the human colorectal cancer microbiome[J]. GUT PATHOGENS,2013,5(X):e2. |
| APA | Geng JW,Fan H,Tang XD,Zhai HQ,&Zhang ZG[*].(2013).Diversified pattern of the human colorectal cancer microbiome.GUT PATHOGENS,5(X),e2. |
| MLA | Geng JW,et al."Diversified pattern of the human colorectal cancer microbiome".GUT PATHOGENS 5.X(2013):e2. |
入库方式： OAI收割
来源：昆明动物研究所
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