Subclinical infections of cardiac implantable electronic devices: Insights into the host-bacteria dialog from blood and pocket tissue with pyrosequencing
文献类型：期刊论文
| 作者 | Zou T1; Zhang ZG[*]2; Zou CG3; Chen KP4; Dai Y4; Tong JB1; Yu X1; Liu JP1; Chen DK5; Xue HT5 |
| 刊名 | INTERNATIONAL JOURNAL OF CARDIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 174期号:3页码:545-549 |
| 关键词 | CIED Subclinical Infection Inflammation Pyrosequencing |
| 通讯作者 | zhangzhigang@mail.kiz.ac.cn ; yangjiefu2011@126.com |
| 合作状况 | 其它 |
| 英文摘要 | While bacteria exist in CIED patients without clinical signs of infection, the underlying bacterial community structure and diversity in the bloodstream and pocket tissue of asymptomatic CIED patients remain unknown. In this study, we performed high-throughput 454 pyrosequencing of bacterial 16S rDNA of blood and pocket tissue from 54 asymptomatic CIED patients as well as blood from 30 normal individuals (normal controls). Firstly, we observed a significant increase of blood bacterial diversity in patients as compared with blood of normal subjects or patient tissues. We also found significant differences in 13 blood-associated bacterial genera between patients and normal subjects, and 14 bacteria genera between blood and tissues within patients. Secondly, we found that the serum levels of four inflammatory markers (CRP, IL-1 beta, IL-6, and MCP-1) in CIED patients were significantly higher than those in normal subjects. Thirdly, we found that there were significant correlations between 43 bacterial species and these inflammatory markers. Taken together, our results reveal a high diversity in the microbial community in CIED patients, and suggest the potential roles of multiple bacteria co-occurrence in the CIED subclinical infections. |
| 资助信息 | This work was supported by a grant (81170171) from the National Natural Science Foundation of China. |
| 语种 | 英语 |
| WOS记录号 | WOS:000339261400028 |
| 公开日期 | 2014-10-15 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8034]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Cardiology, Beijing Hospital, Beijing 100730, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, China 4.Department of Cardiology, Fuwai Hospital, Beijing 100037, China 5.Department of Clinical Chemistry, Beijing Hospital, Beijing 100730, China |
| 推荐引用方式 GB/T 7714 | Zou T,Zhang ZG[*],Zou CG,et al. Subclinical infections of cardiac implantable electronic devices: Insights into the host-bacteria dialog from blood and pocket tissue with pyrosequencing[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2014,174(3):545-549. |
| APA | Zou T.,Zhang ZG[*].,Zou CG.,Chen KP.,Dai Y.,...&Yang JF[*].(2014).Subclinical infections of cardiac implantable electronic devices: Insights into the host-bacteria dialog from blood and pocket tissue with pyrosequencing.INTERNATIONAL JOURNAL OF CARDIOLOGY,174(3),545-549. |
| MLA | Zou T,et al."Subclinical infections of cardiac implantable electronic devices: Insights into the host-bacteria dialog from blood and pocket tissue with pyrosequencing".INTERNATIONAL JOURNAL OF CARDIOLOGY 174.3(2014):545-549. |
入库方式： OAI收割
来源：昆明动物研究所
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