Co-occurrence of driver and passenger bacteria in human colorectal cancer
文献类型：期刊论文
| 作者 | Geng JW1; Song QF4; Tang XD3; Liang X1; Fan H3; Peng HL5; Guo Q[*]3; Zhang ZG[*]2 |
| 刊名 | GUT PATHOGENS
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:X页码:e26 |
| 关键词 | CRC Driver bacteria Passenger bacteria Co-occurrence |
| 通讯作者 | gqkj003@sina.com ; zhangzhigang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Both genetic and epigenetic alterations have been reported to act as driving forces of tumorigenesis in colorectal cancer (CRC), but a growing body of evidence suggests that intestinal microbiota may be an aetiological factor in the initiation and progression of CRC. Recently, the "driver-passenger" model for CRC has connected these different factors, but little has been done to characterize the CRC gut microbiome. Findings: Building on the driver-passenger model, we used 454 pyrosequencing of bacterial 16S rRNA genes associated with 10 normal, 10 adenoma, and 8 tumor biopsy samples, and found 7 potential driver bacterial genera and 12 potential passenger bacterial genera (7 being pro-inflammatory and 5 anti-inflammatory). Further analysis also showed certain co-expression patterns among different clusters of bacteria that may potentially be related to the promotion or progression of gut cancers. Conclusions: The present findings provide preliminary experimental evidence supporting the proposition of bacterial "driver-passenger model" for CRC, and identified potentially novel microbial agents that may be connected to risk of CRC in a Han Chinese population. |
| 资助信息 | This research was supported by the following grants: National Natural Science Foundation of China (NSFC) (Grant No. 31100916) and Natural Science Foundation of Yunnan Province of China (Grant No. 2011FA035 and No. 2013FB196). |
| 语种 | 英语 |
| WOS记录号 | WOS:000338588100001 |
| 公开日期 | 2014-10-15 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8036]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Infectious Diseases, The First People’s Hospital of Yunnan Province, Kunming 650032, Chin 2.State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary & Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming 650032, China 4.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China 5.Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China |
| 推荐引用方式 GB/T 7714 | Geng JW,Song QF,Tang XD,et al. Co-occurrence of driver and passenger bacteria in human colorectal cancer[J]. GUT PATHOGENS,2014,26(X):e26. |
| APA | Geng JW.,Song QF.,Tang XD.,Liang X.,Fan H.,...&Zhang ZG[*].(2014).Co-occurrence of driver and passenger bacteria in human colorectal cancer.GUT PATHOGENS,26(X),e26. |
| MLA | Geng JW,et al."Co-occurrence of driver and passenger bacteria in human colorectal cancer".GUT PATHOGENS 26.X(2014):e26. |
入库方式： OAI收割
来源：昆明动物研究所
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