Lipidome determinants of maximal lifespan in mammals
文献类型：期刊论文
| 作者 | Bozek K1,2,13; Khrameeva EE3,4; Lewin GR[*]6; Azpurua J8; Gorbunova V8; Liu Z11; Shi P11; Willmitzer L12; Reznick J5; Giavalisco P12 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:X页码:e5 |
| 其他题名 | kasia.bozek@oist.jp;giavalisco@mpimp-golm.mpg.de;khaitovich@eva.mpg.de |
| 通讯作者 | kasia.bozek@oist.jp ; giavalisco@mpimp-golm.mpg.de ; khaitovich@eva.mpg.de |
| 英文摘要 | Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammal |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (grant 31420103920), Strategic Priority Research Program of the Chinese Academy of Sciences (grant XDB13010200), the National Natural Science Foundation of China (grant 91331203), the National One Thousand Foreign Experts Plan (grant WQ20123100078), the Bureau of International Cooperation, Chinese Academy of Sciences (grant GJHZ201313) and the Federal Targeted Program for Research and Development in Priority Areas of Advancement of the Russian Scientific and Technological Complex for 2014–2020 (the Ministry of Education and Science of the Russian Federation), grant № 14.615.21.0002, the Unique identifier of the agreement: RFMEFI61515×0002. Additional support was obtained from the European Research Council (advanced grant 294678 to GRL). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10833]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China 2.Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany 3.Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia 4.Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoy Karetny per. 19/1, Moscow, 127051, Russia 5.Max-Delbrück Center for Molecular Medicine, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa 6.Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany 7.Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa 8.University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA 9.SILABE, Primatology Center, University Louis Pasteur, Strasbourg, 4 Rue Blaise Pascal, 67070, France 10.MR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France |
| 推荐引用方式 GB/T 7714 | Bozek K,Khrameeva EE,Lewin GR[*],et al. Lipidome determinants of maximal lifespan in mammals[J]. SCIENTIFIC REPORTS,2017,7(X):e5. |
| APA | Bozek K.,Khrameeva EE.,Lewin GR[*].,Azpurua J.,Gorbunova V.,...&Bennett NC.(2017).Lipidome determinants of maximal lifespan in mammals.SCIENTIFIC REPORTS,7(X),e5. |
| MLA | Bozek K,et al."Lipidome determinants of maximal lifespan in mammals".SCIENTIFIC REPORTS 7.X(2017):e5. |
入库方式： OAI收割
来源：昆明动物研究所
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