Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus
文献类型：期刊论文
| 作者 | Wan LS1; Nian Y2; Geng CA1; Zuo ZL1; Li XN1; Yang J2,3; Zhou M[*]2,4; Qiu MH[*]1; Ye CJ2,3; Shao LD1 |
| 刊名 | Organic Letters
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:9页码:2166-2169 |
| 通讯作者 | mingzhou@mail.kiz.ac.cn ; mhchiu@mail.kib.ac.cn |
| 英文摘要 | Euphorbia peplus has been used in traditional medicine to treat asthma and psoriasis. Three highly modified diterpenoids, namely, pepluacetal (1) and pepluanol A-B (2-3), have been isolated and identified from this plant. Compounds 1-3 exhibit unprecedented 5/4/7/3, 5/6/7/3, and 5/5/8/3 ring systems, respectively. Their structures with absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and electronic circular dichroism calculations. Since Kv1.3 is a validated target for the treatment of autoimmune diseases, such as multiple sclerosis, type-1 diabetes, asthma, and psoriasis, Kv1.3 was studied in terms of its response to the new compounds. All three compounds inhibit Kv1.3, with compound 3 being the most effective with an IC50 value of 9.50 μM. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (81403050 to L.-S.W. and 31370821 to J.Y.), High-Level Overseas Talents of Yunnan Province (to M.Z. and J.Y.), NSFC-Joint Foundation of Yunnan Province (U1132604 to M.-H.Q.), the Top Talents Program of Yunnan Province (2011HA012 to J.Y.), the key medicinal project of Yunnan Province (2015ZJ002 to J.Y.), and the state key project “973”fromtheMOSToftheP.R.China(2014CB910300toJ.Y. and M.Z.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10800]  |
| 专题 | 昆明动物研究所_离子通道药物研发中心 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China 2.Key Laboratory of Animal Models and Human Diease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P. R. China 3.Department of Biological Sciences, Columbia University, New York, New York 10027, United States 4.Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, United States |
| 推荐引用方式 GB/T 7714 | Wan LS,Nian Y,Geng CA,et al. Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus[J]. Organic Letters,2016,18(9):2166-2169. |
| APA | Wan LS.,Nian Y.,Geng CA.,Zuo ZL.,Li XN.,...&Peng XR.(2016).Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus.Organic Letters,18(9),2166-2169. |
| MLA | Wan LS,et al."Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus".Organic Letters 18.9(2016):2166-2169. |
入库方式： OAI收割
来源：昆明动物研究所
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