高分子聚合物HFMC注入猕猴输精管后附睾的远期组织病理学变化
文献类型：期刊论文
| 作者 | 岳利民1; 何亚平1; 罗自强1; 姚先莹1; 李光蓉1; 张金虎1; 白寿昌2; 邹淑荃2; 徐若璞3 |
| 刊名 | 动物学研究
 |
| 出版日期 | 1995 |
| 卷号 | 16期号:2页码:173-177 |
| 关键词 | 高分子聚合物HFMC 猕猴 附睾 |
| ISSN号 | 0254-5853 |
| 其他题名 | Long-Term Histo-Pathological Changes of Rhesus Monkey Epididymides By Intra-Vasa Deferens Injection of Hfmc |
| 中文摘要 | 该实验采用７只成年雄性猕猴, 经双侧阴囊上方切口暴露输精管, 由近附睾端向远侧注射高分子聚合物HFMC, 剂量分别为30mg/侧(1只),60mg/侧(3只), 100mg/侧(3只), 分别于术后２2.5及3.5年处死动物, 取附睾组织进行光镜及电镜观察. 结果表明: 注射不同剂量 HFMC 2.5年后, 动物附晕头、体、尾各部光镜观察所见主要改变为上皮细胞局灶性轻度水样变性, 少许上皮细胞脱落, 个别管腔扩张, 局部间质少量炎细胞浸润. 3.5年后取材光镜观察附睾组织无明显异常. 不同时间取材进行电镜观察所见超微结构变化主要为上皮细胞内线粒体肿胀, 部分线粒体及内织网呈空泡改变, 附睾管腔内精子均有一定程度损伤。 |
| 英文摘要 | Seven male rhesus monkeys were used for the investigation of the histopathological changes of epididymides in the 2.5th and 3.5th years after intra-vasa deferens injection of high molecular polymer HFMC.Various dosages of HFMC(Hydrogel for male contraception)were given to the animals:30 mg per vas deferens for 1 animal,60 mg for 3 and 100 mg for 3.The light microscopic observation showed that there were slight local watery degeneration of epididymal epithelium,falling of some epithelial cells and expansion of lumen in some epididymal tubules in the 2.5th year following intra vas injection of HFMC but no obvious abnormality was found under light microscope in the 3.5th year.The main ultrastructure changes in the 2.5th year showed the swelling of mitochondria,slight vacuolar change of endoplasmic reticulum and damage of sperms in the epididymal tubles.The ultrastructure changes in the 3.5th year were similar to those in the 2.5th year.It is suggested that HFMC may directly or indirectly affect the epididymal structure and the epididymal enviroment due to its gradual release of H[+] as well as its partial and temporary occlusion of vasa deferens.This may be one of the reasons for its male contraceptive action.However,it seems that pathological may be restored after HFMC is progressively dissolved and excereted. |
| 收录类别 | 其他 |
| 原文出处 | 1995162173.pdf |
| 语种 | 中文 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3409]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.华西医科大学,成都610041 2.中国科学院昆明动物研究所,昆明650223 3.中国科学院成都有机化学研究所,成都610044 |
| 推荐引用方式 GB/T 7714 | 岳利民,何亚平,罗自强,等. 高分子聚合物HFMC注入猕猴输精管后附睾的远期组织病理学变化[J]. 动物学研究,1995,16(2):173-177. |
| APA | 岳利民.,何亚平.,罗自强.,姚先莹.,李光蓉.,...&徐若璞.(1995).高分子聚合物HFMC注入猕猴输精管后附睾的远期组织病理学变化.动物学研究,16(2),173-177. |
| MLA | 岳利民,et al."高分子聚合物HFMC注入猕猴输精管后附睾的远期组织病理学变化".动物学研究 16.2(1995):173-177. |
入库方式： OAI收割
来源：昆明动物研究所
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