Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys
文献类型：期刊论文
| 作者 | Ou LY1; Tang XC2; Cai JX[*]1 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2001 |
| 卷号 | 433期号:2-3页码:151-156 |
| 关键词 | Catecholamine Huperzine A Working memory Reserpine Yohimbine (Monkey) |
| ISSN号 | 0014-2999 |
| 通讯作者 | caijx@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The effect of huperzine A, a reversible and selective acetylcholinesterase inhibitor, on reserpine- or yohimbine-induced spatial working memory deficits in monkeys has been examined using the delayed response task that depends on the integrity of prefrontal cortex. Reserpine (0.1 mg/kg, i.m.) or yohimbine (0.01 mg/kg, i.m.) led to significant impairments in the monkeys' ability to perform the delayed response task. Huperzine A (0.01 mg/kg, i.m. in reserpine-treated monkeys; 0.01-0.1 mg/kg, i.m. in yohimbine-treated monkeys) significantly improved the reserpine- or yohimbine-induced memory impairments. The effect of huperzine A on memory impairments exhibited an inverted U-shaped dose-response pattern. Our data suggest that huperzine A may improve working memory via an adrenergic mechanism. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program (G1999054000) of China, National Natural Science Foundation of China (30070251) and Chinese Academy of Sciences (KSCX1-09). |
| 原文出处 | 2001433151.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5195]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Brain and Behavior Section, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
| 推荐引用方式 GB/T 7714 | Ou LY,Tang XC,Cai JX[*]. Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2001,433(2-3):151-156. |
| APA | Ou LY,Tang XC,&Cai JX[*].(2001).Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.EUROPEAN JOURNAL OF PHARMACOLOGY,433(2-3),151-156. |
| MLA | Ou LY,et al."Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys".EUROPEAN JOURNAL OF PHARMACOLOGY 433.2-3(2001):151-156. |
入库方式： OAI收割
来源：昆明动物研究所
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