Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study
文献类型：期刊论文
| 作者 | Yu SM1,2,3; Cai JX[*]1,2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 339期号:3页码:187-190 |
| 关键词 | Aniracetam Transient cerebral ischemia Hippocampus Microdialysis Reverse phase-high performance liquid chromatography Amino acid transmitters Gerbil |
| ISSN号 | 0304-3940 |
| 通讯作者 | caijx@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The effects of aniracetam on extracellular amino acid levels in the hippocampus of conscious gerbils, with or without transient cerebral ischemia/reperfusion, were measured by microdialysis and reverse phase-high performance liquid chromatography. Increased extracellular levels of aspartate and glutamate that were observed in the hippocampus of conscious gerbils during transient global forebrain ischemia were reversed by aniracetam. In contrast, the level of extracellular gamma-aminobutyric acid was increased, while taurine was maintained at a higher level than other amino acids by administration of aniracetam (100 mg/kg, p.o.) 60 min before ischemia. Further, in contrast to ischemic animals, administration of aniracetam (100 mg/kg, p.o.) enhanced the release of glutamate and aspartate in the normal gerbil hippocampus. The results suggest that these effects might be due to a partial calcium agonist activity of aniracetam, and that the effects of aniracetam on amino acid levels might be a mechanism of protection against delayed neuronal death in the ischemic hippocampus, thereby improving memory dysfunction induced by ischemia/reperfusion. |
| 收录类别 | SCI |
| 资助信息 | The research was supported by National Key Basic Research program G1999054000, National Natural Sciences Fund of China 30070251 and 39830440, and Yunnan Province Sciences Fund 2000C0006Z |
| 原文出处 | 2003339187.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5285]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Section of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Graduate school of the Chinese Academy of Sciences, Beijing 100039, PR China 3.College of Life Sciences, Anhui University, Hefei 230039, PR China |
| 推荐引用方式 GB/T 7714 | Yu SM,Cai JX[*]. Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study[J]. NEUROSCIENCE LETTERS,2003,339(3):187-190. |
| APA | Yu SM,&Cai JX[*].(2003).Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study.NEUROSCIENCE LETTERS,339(3),187-190. |
| MLA | Yu SM,et al."Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study".NEUROSCIENCE LETTERS 339.3(2003):187-190. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。