Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes
文献类型：期刊论文
| 作者 | Chen BY[*]1,5; Cai JX1; Song LS2; Wang XQ3; Chen ZH4 |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2005 |
| 卷号 | 76期号:10页码:1111-1121 |
| 关键词 | Ginkgo biloba extract Sodium channel current Potassium channel current Calcium channel current Ventricular myocytes |
| ISSN号 | 0024-3205 |
| 通讯作者 | bichen@iupui.edu |
| 英文摘要 | Ginkgo biloba extract (GBE), a valuable natural product for cerebral and cardiovascular diseases, is mainly composed of two classes of constituents: terpene lactones (e.g., ginkgolide A and B, bilobalide) and flavone glycosides (e.g., quercetin and kaempferol). Its electrophysiological action in heart is yet unclear. In the present study, using whole-cell patch clamp technique, we investigated electrophysiological effects of GBE on cation channel currents in ventricular myocytes isolated from rat hearts. We found that GBE 0.01-0.1% inhibited significantly the sodium current (I(Na)), L-type calcium current (I(Ca)) and transient outward potassium current (IK(to)) in a concentration-dependent manner. Surprisingly, its main ingredients, ginkgolide A (GB A), ginkgolide B (GB B) and bilobalide (GB BA) at 0.1 mM did not exhibit any significant effect on these cation channel currents. These results suggested that GBE is a potent non-selective cation channel modulator in cardiaomyocytes. Other constituents (rather than GB A, GB B and GB BA) might be responsible for the observed inhibitory effects of GBE on cation channels. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grant from Yunnan Provincial Natural Scientific Foundation, China (2000C0080M). |
| 原文出处 | 2005761111.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5351]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Section of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD, USA 3.Department of Physiology, Kunming Medical College, Kunming, China 4.Yunnan Province Key Laboratory of Pharmacology for Natural Products, Kunming Medical College, Kunming, China 5.Division of Gastroentology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA |
| 推荐引用方式 GB/T 7714 | Chen BY[*],Cai JX,Song LS,et al. Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes[J]. LIFE SCIENCES,2005,76(10):1111-1121. |
| APA | Chen BY[*],Cai JX,Song LS,Wang XQ,&Chen ZH.(2005).Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.LIFE SCIENCES,76(10),1111-1121. |
| MLA | Chen BY[*],et al."Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes".LIFE SCIENCES 76.10(2005):1111-1121. |
入库方式： OAI收割
来源：昆明动物研究所
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