Relationship between polymorphisms in the 5 ' leader cistron, positions 16 and 27 of the adrenergic beta 2 receptor gene and asthma in a Han population from southwest China
文献类型：期刊论文
| 作者 | Fu WP1; Zhao ZH1; Zhong L2; Sun C3; Fang LZ1; Liu L1; Zhang JQ1; Wang L1; Shu JK1; Wang XM1 |
| 刊名 | RESPIROLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 16期号:8页码:1221-1227 |
| 关键词 | asthma beta 2-adrenergic receptor beta 2-agonist therapy polymorphism |
| 通讯作者 | dailuming@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Background and objective: Adrenergic beta 2 receptors (ADRB2) play an important role in regulating pulmonary function. Many previous studies have investigated possible associations between polymorphisms in the ADRB2 gene and asthma, but have yielded conflicting results. Furthermore, little is known regarding the possible role of the Arg19Cys polymorphism in susceptibility to asthma among Chinese. Methods: This case-control association study involved 238 patients with asthma and 265 healthy subjects from a Han population in southwest China. For all subjects, the 5' leader cistron Arg19Cys, Arg16Gly and Gln27Glu polymorphisms in the ADRB2 gene were characterized by direct sequencing. Genotype, allele and haplotype frequencies were determined. In addition, to evaluate the association between the ADRB2 polymorphisms and lung function, bronchodilator response to inhaled beta 2 agonists (400 mu g of albuterol) was assessed in the asthmatic patients. Results: There were no significant differences in genotype or allele frequencies for the three ADRB2 polymorphisms between the two cohorts. The Arg19/Arg16/Gln27 haplotype was more frequent among asthmatic patients than control subjects (odds ratio 2.24, 95% confidence interval (CI): 1.05-4.73, P = 0.04). Moreover, the Arg19/Cys19 genotype was associated with a lower FEV(1)% (mean difference -4.5, 95% CI: -12.5 to 3.6, P = 0.02) and FEV(1)/FVC (mean difference 8.9, 95% CI: 8.5-9.4, P = 0.01). The bronchodilator response to albuterol was also marginally lower in individuals who were homozygous for the Arg19 genotype (mean difference 4.2, 95% CI: 3.7-4.8, P = 0.03). Conclusions: The Arg19/Cys19 genotype was an independent risk factor for lower FEV(1)% and FEV(1)/FVC. Asthmatic patients with the Arg19/Arg19 genotype showed decreased responsiveness to albuterol. Furthermore, the Arg19/Arg16/Gln27 haplotype may contribute to increased susceptibility to asthma in the Chinese population. |
| 收录类别 | SCI |
| 资助信息 | This work was performed at Kunming Institute of Zoology, Chinese Academy of Sciences, and the First Affiliated Hospital of Kunming Medical College, and was sup- ported by the Natural Sciences Foundation ofYunnan Province and Natural Sciences Foundation of China (NSFC 2007ZC119). |
| 语种 | 英语 |
| 公开日期 | 2011-11-25 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6827]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Department of Respiratory Critical Care Medicine, The First Affiliated Hospital of Kunming Medical College 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Fu WP,Zhao ZH,Zhong L,et al. Relationship between polymorphisms in the 5 ' leader cistron, positions 16 and 27 of the adrenergic beta 2 receptor gene and asthma in a Han population from southwest China[J]. RESPIROLOGY,2011,16(8):1221-1227. |
| APA | Fu WP.,Zhao ZH.,Zhong L.,Sun C.,Fang LZ.,...&Dai LM[*].(2011).Relationship between polymorphisms in the 5 ' leader cistron, positions 16 and 27 of the adrenergic beta 2 receptor gene and asthma in a Han population from southwest China.RESPIROLOGY,16(8),1221-1227. |
| MLA | Fu WP,et al."Relationship between polymorphisms in the 5 ' leader cistron, positions 16 and 27 of the adrenergic beta 2 receptor gene and asthma in a Han population from southwest China".RESPIROLOGY 16.8(2011):1221-1227. |
入库方式： OAI收割
来源：昆明动物研究所
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