中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster

文献类型:期刊论文

作者Weiner AK1; Ramirez A1; Zintel T1; Rose RW1; Wolff E1; Parker AL1; Bennett K1; Johndreau K1; Rachfalski C1; Zhou J2
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2014
卷号101期号:X页码:7-13
关键词Endocrine Non-monotonic dose-response curve Body size Toxicant Pupariation Development
通讯作者smiths@arcadia.edu
合作状况其它
英文摘要Exposure to Bisphenol A (BPA) has been reported to dysregulate endocrine pathways in a wide array of vertebrate species. The effects of BPA on invertebrate species are less well understood. We tested the effects of BPA on growth and development in Drosophila as these processes are governed by well-studied endocrine pathways. In this study, we tested the effects of three concentrations of BPA (0.1 mg/L, 1 mg/L or 10 mg/L) and found a statistically significant increase in larval growth for the low dose treatment group (0.1 mg/L), but not statistically significant for the high dose treatment group (10 mg/L). BPA exposure resulted in an increased body size in treated animals at 48, 72 and 96 h after egg laying (AEL). This finding reflects a non-monotonic dose-response that has been observed for an increasing number of endocrine disrupting compounds. The increase in growth rate found for all treatment groups was associated with a statistically significant increase in food intake observed at 72 h AEL. Furthermore, we observed that the increased growth rate was coupled with an earlier onset of pupariation consistent with previously reported phenotypes resulting from increased activity of insulin/insulin growth factor signaling (IIS) in Drosophila. Since the timing of the onset of pupariation in Drosophila is controlled through the complex interaction of the IIS and the ecdysone signaling pathways, our findings suggest that BPA exerts its effects through disruption of endocrine signaling in Drosophila.
收录类别SCI
资助信息This work was supported by a research grant from the Stacy Anne Vitetta Professorship Award, Arcadia University.
WOS记录号WOS:000331853400002
公开日期2014-04-04
源URL[http://159.226.149.42:8088/handle/152453/7832]  
专题昆明动物研究所_其他
作者单位1.Arcadia University, 450 South Easton Road, Glenside, PA 19038, USA
2.Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan Province 650223, China
推荐引用方式
GB/T 7714
Weiner AK,Ramirez A,Zintel T,et al. Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2014,101(X):7-13.
APA Weiner AK.,Ramirez A.,Zintel T.,Rose RW.,Wolff E.,...&Smith ST[*].(2014).Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,101(X),7-13.
MLA Weiner AK,et al."Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 101.X(2014):7-13.

入库方式: OAI收割

来源:昆明动物研究所

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