Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster
文献类型：期刊论文
| 作者 | Weiner AK1; Ramirez A1; Zintel T1; Rose RW1; Wolff E1; Parker AL1; Bennett K1; Johndreau K1; Rachfalski C1; Zhou J2 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2014 |
| 卷号 | 101期号:X页码:7-13 |
| 关键词 | Endocrine Non-monotonic dose-response curve Body size Toxicant Pupariation Development |
| 通讯作者 | smiths@arcadia.edu |
| 合作状况 | 其它 |
| 英文摘要 | Exposure to Bisphenol A (BPA) has been reported to dysregulate endocrine pathways in a wide array of vertebrate species. The effects of BPA on invertebrate species are less well understood. We tested the effects of BPA on growth and development in Drosophila as these processes are governed by well-studied endocrine pathways. In this study, we tested the effects of three concentrations of BPA (0.1 mg/L, 1 mg/L or 10 mg/L) and found a statistically significant increase in larval growth for the low dose treatment group (0.1 mg/L), but not statistically significant for the high dose treatment group (10 mg/L). BPA exposure resulted in an increased body size in treated animals at 48, 72 and 96 h after egg laying (AEL). This finding reflects a non-monotonic dose-response that has been observed for an increasing number of endocrine disrupting compounds. The increase in growth rate found for all treatment groups was associated with a statistically significant increase in food intake observed at 72 h AEL. Furthermore, we observed that the increased growth rate was coupled with an earlier onset of pupariation consistent with previously reported phenotypes resulting from increased activity of insulin/insulin growth factor signaling (IIS) in Drosophila. Since the timing of the onset of pupariation in Drosophila is controlled through the complex interaction of the IIS and the ecdysone signaling pathways, our findings suggest that BPA exerts its effects through disruption of endocrine signaling in Drosophila. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a research grant from the Stacy Anne Vitetta Professorship Award, Arcadia University. |
| WOS记录号 | WOS:000331853400002 |
| 公开日期 | 2014-04-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7832]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Arcadia University, 450 South Easton Road, Glenside, PA 19038, USA 2.Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan Province 650223, China |
| 推荐引用方式 GB/T 7714 | Weiner AK,Ramirez A,Zintel T,et al. Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2014,101(X):7-13. |
| APA | Weiner AK.,Ramirez A.,Zintel T.,Rose RW.,Wolff E.,...&Smith ST[*].(2014).Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,101(X),7-13. |
| MLA | Weiner AK,et al."Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 101.X(2014):7-13. |
入库方式： OAI收割
来源：昆明动物研究所
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