Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats
文献类型：期刊论文
| 作者 | Zhang M; Cai JX[*] |
| 刊名 | NEUROBIOLOGY OF LEARNING AND MEMORY
 |
| 出版日期 | 2008 |
| 卷号 | 89期号:4页码:397-406 |
| 关键词 | tactile stimulation maternal separation working memory synaptic plasticity dopamine |
| 通讯作者 | caijx@post.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counteracted by repeated short periods of maternal separation (NIS). Wistar rat pups submitted to TS were handled and marked transiently per day during postnatal days 2-9 or 10-17. TS/MS pups were stimulated in the same way as TS pups and then individually separated from their mother for 1 h/day. Their nontactile stimulated (NTS) siblings served as controls. In adulthood, TS and TS/MS rats showed better performance in two versions of the delayed alternation task and superior in vivo long-term potentiation of the hippocampo-prefrontal cortical pathway when compared with controls. Furthermore, there were more doses of A77636 (a selective dopamine DI agonist) to significantly improve SWM performance in TS and TS/MS rats than in NTS rats, suggesting that activation of prefrontal DI receptors in TS and TS/MS rats is more optimal for SWM function than in NTS rats. NIS did not counteract TS-induced effects because no significant difference was found between TS/MS and TS animals. These data indicate that in early life, external tactile stimulation leads to long-term facilitative effects in SWM-related neural function. |
| 资助信息 | This work was supported by the National Natural Science Foundation (30070251) and the National Basic Research Program (G1999054000) of China to Prof. Jing-Xia Cai. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9628]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | Division of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang East Road, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Zhang M,Cai JX[*]. Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2008,89(4):397-406. |
| APA | Zhang M,&Cai JX[*].(2008).Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats.NEUROBIOLOGY OF LEARNING AND MEMORY,89(4),397-406. |
| MLA | Zhang M,et al."Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats".NEUROBIOLOGY OF LEARNING AND MEMORY 89.4(2008):397-406. |
入库方式： OAI收割
来源：昆明动物研究所
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